67776-06-1
(2R)-2-(acetylamino)-3-methyl-3-(nitrososulfanyl)butanoate
CAS: 67776-06-1
Molecular Formula: C7H12N2O4S
67776-06-1 - Names and Identifiers
| Name | (2R)-2-(acetylamino)-3-methyl-3-(nitrososulfanyl)butanoate |
| Synonyms | SNAP N-(ACETYLOXY)-3-NITROSOTHIOVALINE S-NITROSO-N-ACETYL-D,L-PENICILLAMINE S-Nitroso-N-acetylpenicillamine, SNAP SNAP [S-Nitroso-N-acetylpenicillaMine] Anti-SNAP25, C-Terminal antibody produced in rabbit (R)-2-acetaMido-3-Methyl-3-(nitrosothio)butanoic acid (2R)-2-(acetylamino)-3-methyl-3-(nitrososulfanyl)butanoate S-Nitroso-N-acetyl-DL-penicillamine,N-Acetyl-3-(nitrosothio)-DL-valine |
| CAS | 67776-06-1 |
| InChI | InChI=1/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12)/p-1/t5-/m1/s1 |
67776-06-1 - Physico-chemical Properties
| Molecular Formula | C7H12N2O4S |
| Molar Mass | 220.246 |
| Density | 1.4261 (rough estimate) |
| Melting Point | 150.5°C |
| Appearance | Morphological powder |
| Color | green |
| pKa | 3.06±0.10(Predicted) |
| Storage Condition | -20°C |
| Sensitive | `sensitive` to humidity and light |
| Refractive Index | 1.5400 (estimate) |
| MDL | MFCD00272624 |
| Use | Nitric oxide (NO) donor; vasodilator, smooth muscle relaxant, lymphocyte activator. |
67776-06-1 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | YV9383000 |
67776-06-1 - Upstream Downstream Industry
| Downstream Products | N-ACETYL-DL-PENICILLAMINE N-ACETYL-3-MERCAPTO-D-VALINE |
67776-06-1 - Nature
| Solubility | H2O: ≥2 mg/mL |
Last Update：2024-04-10 22:29:15
67776-06-1 - Uses and synthesis methods
biological activity
S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a nitric oxide donor and a stable platelet aggregation inhibitor.
in vitro studies
S-Nitroso-N-acetyl-DL-penicillamine (10 mM; 8 hours) induces toxicity of about 80% after 6 hours under normoxic conditions by releasing nitric oxide (NO).
S-Nitroso-N-acetyl-DL-penicillamine has a half-time about 6 hours in in isolated rat ventricular myocytes.
S-Nitroso-N-acetyl-DL-penicillamine (100 µM; 30 minutes) causes sustained decrease in the basal pHi in isolated rat ventricular myocytes.
Cell Viability Assay
Cell Line: Rat liver sinusoidal endothelial cells
Concentration: 2 mM, 5 mM, 10 mM
Incubation Time: 2 hours, 4 hours, 6 hours, 8 hours
Result: Exhibited cytotoxicity against cultivated endothelial cells.
In vivo studies
SNAP (100μM, 300μM) causes small but significant increases of the electrically evoked [ 3 H]-acetylcholine release in guinea-pig tracheal.
Last Update：2024-04-10 22:29:15
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Tel: 0712-8899838
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Product Name: SNAP [S-Nitroso-N-acetylpenicillamine] Request for quotationCAS: 67776-06-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
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Wechat: 18916960931
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Product Name: SNAP [S-Nitroso-N-acetylpenicillamine] Visit Supplier Webpage Request for quotationCAS: 67776-06-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: SNAP Visit Supplier Webpage Request for quotationCAS: 67776-06-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: SNAP [S-Nitroso-N-acetylpenicillamine] Visit Supplier Webpage Request for quotationCAS: 67776-06-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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