69541-68-0
Boc-D-His(Tos)-OH
CAS: 69541-68-0
Molecular Formula: C18H23N3O6S
69541-68-0 - Names and Identifiers
69541-68-0 - Physico-chemical Properties
| Molecular Formula | C18H23N3O6S |
| Molar Mass | 409.46 |
| Storage Condition | Sealed in dry,2-8°C |
69541-68-0 - Introduction
Boc-D-His(Tos)-OH(Boc-D-His(Tos)-OH) is a chemical substance that has the following properties:
Nature:
1. Appearance: white solid
2. molecular formula: C21H25N3O6S
3. molecular weight: 443.51
4. Melting point: about 110-115°C
Use:
Boc-D-His(Tos)-OH is commonly used in organic synthesis as a protecting group for D-histidine (D-His). Its main uses include:
1. In the synthesis of a polypeptide, it is used to synthesize a polypeptide sequence containing a D-histidine protecting group.
2. Used as an intermediate in the field of medicinal chemistry for the synthesis of biologically active target compounds.
3. Design and synthesis of drug candidate compounds in research.
Preparation Method:
The preparation of Boc-D-His(Tos)-OH is usually carried out by the following steps:
1. D-histidine (D-His) was reacted with p-toluenesulfonyl chloride (p-toluenesulfonyl chloride) to give D-histidine p-toluenesulfonyl (D-His-Tos).
2. Under alkaline conditions, D-His-Tos is reacted with n-butoxycarbonylhydrazine (tert-butyloxycarbonylhydrazide) to generate Boc-D-His(Tos)-OH.
Safety Information:
The safety evaluation of Boc-D-His(Tos)-OH is limited, but as a chemical substance, the following safety considerations should be noted:
1. Avoid inhalation, contact with skin and eyes. Wear appropriate personal protective equipment, such as gloves and glasses.
2. Good laboratory practices should be followed during use and good ventilation conditions should be ensured.
3. Store in a sealed container, away from fire and oxidant.
4. Follow relevant regulations and guidelines during processing.
When using Boc-D-His(Tos)-OH, please be sure to follow the relevant laboratory safety regulations and operating instructions, and properly store and handle chemicals. If necessary, it is recommended to operate under the guidance of professionals.
Nature:
1. Appearance: white solid
2. molecular formula: C21H25N3O6S
3. molecular weight: 443.51
4. Melting point: about 110-115°C
Use:
Boc-D-His(Tos)-OH is commonly used in organic synthesis as a protecting group for D-histidine (D-His). Its main uses include:
1. In the synthesis of a polypeptide, it is used to synthesize a polypeptide sequence containing a D-histidine protecting group.
2. Used as an intermediate in the field of medicinal chemistry for the synthesis of biologically active target compounds.
3. Design and synthesis of drug candidate compounds in research.
Preparation Method:
The preparation of Boc-D-His(Tos)-OH is usually carried out by the following steps:
1. D-histidine (D-His) was reacted with p-toluenesulfonyl chloride (p-toluenesulfonyl chloride) to give D-histidine p-toluenesulfonyl (D-His-Tos).
2. Under alkaline conditions, D-His-Tos is reacted with n-butoxycarbonylhydrazine (tert-butyloxycarbonylhydrazide) to generate Boc-D-His(Tos)-OH.
Safety Information:
The safety evaluation of Boc-D-His(Tos)-OH is limited, but as a chemical substance, the following safety considerations should be noted:
1. Avoid inhalation, contact with skin and eyes. Wear appropriate personal protective equipment, such as gloves and glasses.
2. Good laboratory practices should be followed during use and good ventilation conditions should be ensured.
3. Store in a sealed container, away from fire and oxidant.
4. Follow relevant regulations and guidelines during processing.
When using Boc-D-His(Tos)-OH, please be sure to follow the relevant laboratory safety regulations and operating instructions, and properly store and handle chemicals. If necessary, it is recommended to operate under the guidance of professionals.
Last Update：2024-04-09 15:17:59
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CAS: 69541-68-0
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CAS: 69541-68-0
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View History
69541-68-0
126-18-1
622369-70-4
22414-26-2
18419-84-6
Methyl isobutyl oxime
乙酸硅(IV)
1412-19-7
126-81-8
1121-25-1
126-18-1
622369-70-4
22414-26-2
18419-84-6
Methyl isobutyl oxime
乙酸硅(IV)
1412-19-7
126-81-8
1121-25-1