71731-58-3

Name	Tiquizium bromide
Synonyms	Aspora Advaston Gastirol Tiquizium 71731-58-3 TIQUIZIUM BROMIDE Tiquizium bromide (5R,9aR)-3-(Di-2-thienylmethylene)-5-methyloctahydro-2H-quinolizinium bromide 2H-Quinolizinium, 3-(di-2-thienylmethylene)octahydro-5-methyl-, bromide, trans- (5R,9aR)-3-(dithiophen-2-ylmethylidene)-5-methyloctahydro-2H-quinolizinium bromide 2H-Quinolizinium, 3-(di-2-thienylmethylene)octahydro-5-methyl-, bromide, (5R,9aR)-rel- (9CI) (5r,9ar)-7-(dithiophen-2-ylmethylidene)-5-methyl-1,2,3,4,6,8,9,9a-octahydroquinolizin-5-ium bromide
CAS	71731-58-3
EINECS	1312995-182-4
InChI	InChI=1/C19H24NS2.BrH/c1-20-11-3-2-6-16(20)10-9-15(14-20)19(17-7-4-12-21-17)18-8-5-13-22-18;/h4-5,7-8,12-13,16H,2-3,6,9-11,14H2,1H3;1H/q+1;/p-1/t16-,20-;/m1./s1

Molecular Formula	C19H24BrNS2
Molar Mass	410.43
Melting Point	278-281° (dec)
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	White to Off-White
Storage Condition	Refrigerator

effect	the mechanism of action of tequinonium bromide is mainly that it has competitive anti-acetylcholine effect at the muscarinic action site and has selective and powerful antispasmodic effect on visceral smooth muscle such as digestive tract. The inhibitory effect on gastric juice secretion is much stronger than that of scopolamine butyl bromide.
application	tequinonium bromide is suitable for gastritis, gastric and duodenal ulcers, enteritis, allergic colon syndrome and spasticity and hyperkinesia caused by gallbladder and biliary tract diseases.
pharmacokinetics	healthy adults take this product 10mg orally. after 1.5h, the concentration of the original drug in serum reaches the highest value, about 10ng/ml, and the clearance half-life is about 1.4h. More than 90% of the total excretion was excreted within 6 hours, and the total excretion of the original drug within 24 hours was about 0.9% of the dose. The metabolites in the urine, in addition to the original drug, are mainly thiophene ring -0-sulfate, and there are also trace thiophene ring -0-glucuronide. That is, the main metabolic pathway of this product in the human body is the hydroxylation of the thiophene ring.

Last Update：2024-04-09 19:05:04

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