72873-74-6
6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE
CAS: 72873-74-6
Molecular Formula: C16H12FN3S
72873-74-6 - Names and Identifiers
72873-74-6 - Physico-chemical Properties
| Molecular Formula | C16H12FN3S |
| Molar Mass | 297.35 |
| Density | 1.39±0.1 g/cm3(Predicted) |
| Melting Point | 189-190°C(lit.) |
| Boling Point | 476.1±55.0 °C(Predicted) |
| Solubility | DMSO: 9mg/mL, soluble |
| Appearance | solid |
| Color | off-white |
| pKa | 4.36±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| In vitro study | SKF-86002 (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV). SKF-86002 does not inhibit UV-induced apoptosis in undifferentiated HL-60 cells. SKF-86002 (10 μM; 72 hours) prevent IL-4-induced monocyte or U937 cell CD23 surface expression and protein formation with no effect on CD23 mRNA levels. Western Blot Analysis Cell Line: U937 cells Concentration: 10 μM Incubation Time: 72 hours Result: Significantly reduced CD23 levels on IL-4-treated U937 cells. |
| In vivo study | SKF-86002 (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity. Animal Model: Lewis rats, with adjuvant-induced arthritis (AA) Dosage: 10 mg/kg, 30 mg/kg, 90 mg/kg Administration: Oral administration, daily, for 22 days Result: Significantly decreased hindleg volumes after injection of adjuvant. |
72873-74-6 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
72873-74-6 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.363 ml | 16.815 ml | 33.629 ml |
| 5 mM | 0.673 ml | 3.363 ml | 6.726 ml |
| 10 mM | 0.336 ml | 1.681 ml | 3.363 ml |
| 5 mM | 0.067 ml | 0.336 ml | 0.673 ml |
Last Update：2024-01-02 23:10:35
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