757251-39-1
4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
CAS: 757251-39-1
Molecular Formula: C13H12FN3O2
757251-39-1 - Names and Identifiers
757251-39-1 - Physico-chemical Properties
| Molecular Formula | C13H12FN3O2 |
| Molar Mass | 261.25 |
| Density | 1.305 |
| Melting Point | 143 °C |
| Boling Point | 459.8±45.0 °C(Predicted) |
| Flash Point | 231.9°C |
| Solubility | Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly) |
| Vapor Presure | 1.22E-08mmHg at 25°C |
| Appearance | Solid |
| Color | Orange to Dark Red to Brown |
| pKa | 13.92±0.46(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.602 |
757251-39-1 - Reference Information
| Use | 4-(4-amino-3-fluorophenoxy) methylamine pyridine-2-carboxylate is an organic intermediate, which is commonly used as an intermediate of antitumor drugs. |
| preparation | 4-(4-amino-3-fluorophenoxy) pyridine-2-carboxylic acid methylamine can be prepared by a one-step reaction from 4-amino-3-fluorophenol and 4-chloro-n-methylpyridine-2-carboxamide as starting materials. 4-amino-3-fluorophenol (1.27g,10mmol,1.0eq) was added to dried DMF(20ml) and stirred well. Potassium tert-butoxide (1.34g,12mmol,1.0eq) was added and stirred under nitrogen at room temperature for 1H. 4-chloro-n-methylpyridine-2-carboxamide (1.70g,10mmol,1.0eq), heating to 85 deg C to continue the reaction for 10 hours. The reaction solution was quenched with water (100mL), and then extracted with dichloromethane (200mL * 2). The organic phase was dried over anhydrous magnesium sulfate, and the organic phase was spin-dried to obtain an oily liquid, column chromatography (petroleum ether: ethyl acetate = 4:1) was performed to obtain 4-(4-amino-3-fluorophenoxy) pyridine-2-carboxylic acid methylamine (1.3g). |
Last Update：2024-04-09 15:16:40
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