761436-81-1
2-[[5-Bromo-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzenesulfonamide
CAS: 761436-81-1
Molecular Formula: C23H28BrN7O3S
761436-81-1 - Names and Identifiers
761436-81-1 - Physico-chemical Properties
| Molecular Formula | C23H28BrN7O3S |
| Molar Mass | 562.48 |
| Density | 1.472±0.06 g/cm3(Predicted) |
| Boling Point | 724.7±70.0 °C(Predicted) |
| Solubility | DMSO : 50 mg/mL mother liquor preservation: sub-package and freeze storage to avoid repeated freezing and thawing;-20 ℃,1 month;-80 ℃,6 months (after dilution, the solution temperature is low and storage may precipitate, try to use it now) Cell experiment: Dissolve with DMSO first: dilute with culture medium then, and the dilution process is recommended to be carried out in stages to avoid too fast concentration change leading to compound precipitation. If the compound is precipitated during the dilution process, it can be redissolved by ultrasound. During dilution, ensure that the final concentration of DMSO in the working fluid should be below 0.1% as far as possible, and the maximum should not exceed 0.5%, and set up a DMSO control group with corresponding concentration. Animal experiment: Dissolve with DMSO first: dilute with water or normal saline, etc. The dilution process is recommended to be carried out in sections to avoid excessive concentration changes leading to compound p |
| pKa | 11.27±0.10(Predicted) |
| Storage Condition | -20℃ |
| Use | ALK inhibitor 1 (compound 17) is a potent, pyrimidine-based ALK inhibitor. ALK inhibitor 1 is a potent testicular-specific serine/threonine kinase 2 (TSSK2; IC50 = 31 nM) and focal adhesion kinase (FAK; IC50 = 2 nM) inhibitor. |
| In vitro study | ALK inhibitor 1 (compound 17) inhibits IGF-1R with an IC 50 of 90 nM. |
761436-81-1 - Reference
| Reference Show more | 1. Jon E Hawkinson, et al. Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2). ChemMedChem. 2017 Nov 22;12(22):1857-1865. |
761436-81-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.778 ml | 8.889 ml | 17.778 ml |
| 5 mM | 0.356 ml | 1.778 ml | 3.556 ml |
| 10 mM | 0.178 ml | 0.889 ml | 1.778 ml |
| 5 mM | 0.036 ml | 0.178 ml | 0.356 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Multiple SpecificationsSpot supply
Product Name: ALK inhibitor 1 Request for quotationCAS: 761436-81-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: ALK inhibitor 1 Visit Supplier Webpage Request for quotationCAS: 761436-81-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: ALK inhibitor 1 Visit Supplier Webpage Request for quotationCAS: 761436-81-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 2-[[5-Bromo-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzenesulfonamide Visit Supplier Webpage Request for quotationCAS: 761436-81-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Multiple SpecificationsSpot supply
Product Name: ALK inhibitor 1 Request for quotationCAS: 761436-81-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: ALK inhibitor 1 Visit Supplier Webpage Request for quotationCAS: 761436-81-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: ALK inhibitor 1 Visit Supplier Webpage Request for quotationCAS: 761436-81-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 2-[[5-Bromo-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzenesulfonamide Visit Supplier Webpage Request for quotationCAS: 761436-81-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History