78281-02-4
Safflomin A
CAS: 78281-02-4
Molecular Formula: C27H32O16
78281-02-4 - Names and Identifiers
| Name | Safflomin A |
| Synonyms | HSYA SAFFLOMIN A Safflomin A Hydroxysafflor yellow Hydroxysafflor yellow A Hydroxysafflor yellow A,Safflomin A Hydroxysafflor yellow A,SaffloMin A,HSYA 2,5-Cyclohexadien-1-one, 2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-((2E)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl)- |
| CAS | 78281-02-4 |
| InChI | InChI=1/C27H32O16/c28-7-11-16(32)25(43-26(40)17(11)33)27(41)23(38)14(12(31)6-3-9-1-4-10(30)5-2-9)19(35)15(24(27)39)22-21(37)20(36)18(34)13(8-29)42-22/h1-6,11,13,16-18,20-22,25-26,28-30,32-34,36-41H,7-8H2/b6-3+/t11-,13-,16-,17+,18-,20+,21-,22+,25+,26+,27?/m1/s1 |
78281-02-4 - Physico-chemical Properties
| Molecular Formula | C27H32O16 |
| Molar Mass | 612.54 |
| Density | 1.851±0.06 g/cm3(Predicted) |
| Melting Point | 184-186 °C |
| Boling Point | 1015.8±65.0 °C(Predicted) |
| Solubility | DMSO : ≥ 34 mg/mL (55.51 mM);H2O : 33.33 mg/mL (54.41 mM; Need ultrasonic) |
| Appearance | Yellow powder |
| pKa | 4.50±1.00(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.797 |
| MDL | MFCD08435942 |
| Physical and Chemical Properties | Dried flowers derived from the Asteraceae plant safflower Carthamus tinctorius L. |
78281-02-4 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29389090 |
78281-02-4 - Reference Information
| overview | [1] safflower yellow A is a water-soluble component of safflower and has various pharmacological activities such as inhibiting platelet aggregation, antioxidant and anti-inflammatory. It is the main effective component of safflower yellow and sodium chloride injection. Modern pharmacological studies have confirmed that it has a wide range of pharmacological effects in the cardiovascular and cerebrovascular system, blood system, nervous system, anti-oxidation, anti-inflammatory, etc., and it is mainly used in the treatment of cardiovascular and cerebrovascular diseases clinically, and there is no use for aging The report of the disease; it can be seen that the application of monomer components with strong effect of promoting blood circulation and removing blood stasis in the field of anti-aging has great research value and development potential. picture: safflower |
| pharmacological activity research | anti-Alzheimer's disease in vitro: the in vitro efficacy evaluation results show that HSYA can dose-dependently resist neuron-like cell damage caused by Aβ at 20-80 um, maintain the normal morphology of cells and synapses, significantly improve cell survival rate, and significantly reduce the release rate, showing a significant neuroprotective effect. The results of in vitro mechanism study show that HSYA can significantly increase the GSH content and mitochondrial membrane potential ratio in Aβ injured cells, reduce the intracellular content, the expression and level of pro-apoptotic proteins, reduce the formation of debris, and inhibit cell apoptosis. It is suggested that the protective mechanism of nerve cell injury may be through reducing the level, maintaining the level of mitochondrial membrane potential, maintaining the stability of mitochondrial structure and function, and inhibiting the release of mitochondrial apoptosis factors, which plays an important role in protecting the injured nerve cells by affecting the mitochondrial apoptosis pathway. Anti-skin photoaging: HSYA can significantly increase skin water and capacity, maintain its elasticity, and maintain skin macroscopic normal characterization. It can significantly improve the skin structural degeneration (especially the distortion and fracture of collagen fibers and elastic fibers), and maintain the normal distribution of collagen fibers and elastic fibers. It is suggested that external coating can indirectly or directly affect the activity of matrix metalloproteinases through antioxidant effect, inhibit collagen degradation, and further resist skin photoaging damage caused by repeated radiation. Anti-myocardial ischemia effect [3]: Hydroxysafflor yellow A can significantly reduce the myocardial infarction area of myocardial ischemia rats, significantly reduce the production of serum creatine kinase MB type (CK-MB) and lactate dehydrogenase (LDH), and can reduce the blood viscosity and platelet aggregation phenomenon of myocardial ischemia rats, and can prolong the prothrombin time and activated partial thromboplastin time (APTT value) to a certain extent; blood stasis experiments showed that hydroxysafflor yellow A could reduce blood viscosity and inhibit ADP-induced platelet aggregation in blood stasis rats, and also had a certain prolonging effect on PT and APTT values. Hydroxysafflor yellow A may exert its anti-myocardial ischemia effect by improving hemorheology and coagulation function. |
| references | [1] Kong Songzhi. Study on Anti-aging Effect of Hydroxysafflor Yellow A [D]. Guangzhou University of Traditional Chinese Medicine, 2014. [2] Wan Tian, Wu Minrui, qi Zhenxi. Effect of Hydroxysafflor Yellow A on Hormone-induced Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells [J]. Chinese Bone Injury, 2014, 27(03):224-228. |
| biological activity | Hydroxysafflor yellow A is a natural product of flavonoids isolated from traditional Chinese medicine safflower and has anti-cancer activity. |
| chemical properties | dried flowers derived from chrysanthemum plant safflower Carthamus tinctorius l |
| use | used for content determination/identification/pharmacological experiments and other pharmacological effects: it can inhibit platelet aggregation and release induced by platelet activating factor, and can competitively inhibit the binding of platelet activating factor and platelet receptor. It is an effective component of safflower yellow pigment to promote blood circulation and remove blood stasis. It is a good pharmaceutical raw material, can also be used to make health care and cosmetics, and is also a good food dye. Anti-platelet and anti-myocardial ischemia effects. Antithrombin-induced platelet aggregation activity, anti-inflammatory activity, cytoprotective activity, anti-tumor activity. |
Last Update：2024-04-09 21:01:54
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View History
78281-02-4
Sulfatase
1019-52-9
2786-07-4
CALCIUM DIMETHOXIDE
RARECHEM AL BE 0058
EpichoL
Bensulfuron methyl
16-HEXADECANOYL HYDRAZIDE
TRIETHYLOLAMINE HYDROCHLORIDE
Sulfatase
1019-52-9
2786-07-4
CALCIUM DIMETHOXIDE
RARECHEM AL BE 0058
EpichoL
Bensulfuron methyl
16-HEXADECANOYL HYDRAZIDE
TRIETHYLOLAMINE HYDROCHLORIDE