788136-89-0
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate
CAS: 788136-89-0
Molecular Formula: C17H13ClFN3O3
788136-89-0 - Names and Identifiers
| Name | 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate |
| Synonyms | Gefitinib IMpurity VIII Gefitinib interMediate VI 4-((3-Chloro-4-fluorophenyl) -7-methoxyquinazolin-6-yl acetate 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinol 6-acetate 6-Quinazolinol,4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-, 6-acetate acetic acid [4-(3-chloro-4-fluoroanilino)-7-methoxy-6-quinazolinyl] ester |
| CAS | 788136-89-0 |
| InChI | InChI=1/C17H13ClFN3O3/c1-9(23)25-16-6-11-14(7-15(16)24-2)20-8-21-17(11)22-10-3-4-13(19)12(18)5-10/h3-8H,1-2H3,(H,20,21,22) |
788136-89-0 - Physico-chemical Properties
| Molecular Formula | C17H13ClFN3O3 |
| Molar Mass | 361.75 |
| Density | 1.425 |
| Boling Point | 471.5±45.0 °C(Predicted) |
| pKa | 5.22±0.30(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.649 |
788136-89-0 - Introduction
4-(a)-7-methoxyquinazolin-6-yl acetate is an organic compound with the chemical formula C21H15ClFNO4. It has the following characteristics:
1. Appearance: white solid.
2. Melting point: about 180-185°C.
3. Solubility: Soluble in organic solvents.
This ester compound has a wide range of applications in medicine and scientific research. Its main uses include:
1. Drug research: as the research object of anticancer and antiviral drugs.
2. anti-inflammatory drugs: with anti-inflammatory and immunomodulatory properties.
3. biological activity research: can be used to study its interaction and activity in vivo.
The method for preparing 4-(-)-7-methoxyquinazolin-6-yl acetate is to react 4-(3-chloro-4-phenylamino)-7-methoxyquinazoline-6-phenol with acetic anhydride under appropriate reaction conditions.
The safety information of this compound is limited, so care should be taken when using and handling it. It is recommended to use in accordance with the relevant safe practice and to follow the appropriate guidance provided in the Chemical Safety Data Sheet.
1. Appearance: white solid.
2. Melting point: about 180-185°C.
3. Solubility: Soluble in organic solvents.
This ester compound has a wide range of applications in medicine and scientific research. Its main uses include:
1. Drug research: as the research object of anticancer and antiviral drugs.
2. anti-inflammatory drugs: with anti-inflammatory and immunomodulatory properties.
3. biological activity research: can be used to study its interaction and activity in vivo.
The method for preparing 4-(-)-7-methoxyquinazolin-6-yl acetate is to react 4-(3-chloro-4-phenylamino)-7-methoxyquinazoline-6-phenol with acetic anhydride under appropriate reaction conditions.
The safety information of this compound is limited, so care should be taken when using and handling it. It is recommended to use in accordance with the relevant safe practice and to follow the appropriate guidance provided in the Chemical Safety Data Sheet.
Last Update：2024-04-09 20:49:11
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