7ACC2
7ACC2
CAS: 1472624-85-3
Molecular Formula: C18H15NO4
7ACC2 - Names and Identifiers
7ACC2 - Physico-chemical Properties
| Molecular Formula | C18H15NO4 |
| Molar Mass | 309.32 |
| Density | 1.368±0.06 g/cm3(Predicted) |
| Boling Point | 548.9±50.0 °C(Predicted) |
| Solubility | DMSO: ≥ 46 mg/mL |
| pKa | -98.37±0.20(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | 7ACC2 (compound 19; 72 hours) inhibits SiHa cells proliferation in lactate-containing medium with an EC50 of 0.22 μM. In SiHa cells, lactate uptake primarily depends on the high affinity MCT1 transporter. 7ACC2 (compound 19) shows an excellent chemical stability in simulated gastric (SGF) and intestinal (SIF) fluids, a good apparent permeability coefficient (Papp) through Caco-2 monolayer and a high metabolic stability on mouse (MLM) and human liver microsomes (HLM) as well as on human hepatocytes. 7ACC2 is a potent inhibitor of mitochondrial pyruvate transport which consecutively blocks extracellular lactate uptake by promoting intracellular pyruvate accumulation. |
| In vivo study | 7ACC2 (3 mg/kg; intraperitoneal administration; daily; for 5 days or 10days) treatment significantly inhibits tumor growth in mice. 7ACC2 radiosensitizes tumor cells by reducing hypoxia in vivo. The intraperitoneal administration of 7ACC2 (compound 19; 3 mg/kg) to mice leads to a C max of 1246 ng/ml (4 μM) in a very short time (T max =10 min) associated with a plasma half-life of 4.5 h. Animal Model: 7-week-old female NMRI nude mice with radiotherapy administered Dosage: 3 mg/kg Administration: Intraperitoneal administration; daily; for 5 days or 10days Result: A significant increase in tumor growth delay was observed. |
7ACC2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.233 ml | 16.165 ml | 32.329 ml |
| 5 mM | 0.647 ml | 3.233 ml | 6.466 ml |
| 10 mM | 0.323 ml | 1.616 ml | 3.233 ml |
| 5 mM | 0.065 ml | 0.323 ml | 0.647 ml |
Last Update：2024-01-02 23:10:35
7ACC2 - Reference Information
| biological activity | 7ACC2 is a potent MCT1 inhibitor that inhibits lactate absorption in human-derived cervical cell carcinoma of SiHa, the IC50 was 10 nM. |
| Target | TargetValue MCT1 () |
| Target | Value |
| in vitro study | 7ACC2 (compound 19; 72 hours) inhibit SiHa cells in lactate-containing medium with an EC50 of 0.22 μm. In SiHa cells, lactate uptake primary costs on the high affinity MCT1 transporter. 7ACC2 (compound 19) show an excellent chemical stability in simulated gastric (SGF) and Intel Intal (SIF) fluids, a good apparent permeability coefficient (Papp) through Caco-2 monolayer and a high metabolic stability on mouse (MLM) and human liver microsomes (HLM) as well as on human hepatocytes. 7ACC2 is a potent inhibitor of mitochondrial pyruvate transport which consecutively blocks extracellular lactate uptake by promoting intracellular pyruvate accumulation. |
| in vivo study | 7ACC2 (3 mg/kg; Intraparoneal administration; daily; for 5 days or 10days) refer to significantly inhibits tumor growth in mice. 7ACC2 radiosentizes tumor cells by reducing hypoxia in vivo. The intrapeach administration of 7ACC2 (compound 19; 3 mg/kg) to mice leads to a C max of 1246 ng/ml (4 μm) in a very short time (T max =10 min) associated with a plasma half-life of 4.5 h. Animal Model: 7-week-old female NMRI nude mice with radiotherapy administered Dosage: 3 mg/kg Administration: Intraperitoneal administration; daily; for 5 days or 10days Result: A significant increase in tumor growth delay was observed. |
| Animal Model: | 7-week-old female NMRI nude mice with radiotherapy administered |
| Dosage: | 3 mg/kg |
| Administration: | Intraperitoneal administration; daily; for 5 days or 10days |
| Result: | A significant increase in tumor growth delay was observed. |
Last Update：2024-04-10 22:29:15
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