8-Chloro-2-hydroxyquinoline
8-Chloro-2-hydroxyquinoline
CAS: 23981-25-1
Molecular Formula: C9H6ClNO
8-Chloro-2-hydroxyquinoline - Names and Identifiers
8-Chloro-2-hydroxyquinoline - Physico-chemical Properties
| Molecular Formula | C9H6ClNO |
| Molar Mass | 179.6 |
| Density | 1.339±0.06 g/cm3(Predicted) |
| Melting Point | 209-212 °C (lit.) |
| Boling Point | 373.3±42.0 °C(Predicted) |
| pKa | 10.70±0.70(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
8-Chloro-2-hydroxyquinoline - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
8-Chloro-2-hydroxyquinoline - Introduction
It is an organic compound with the chemical formula C9H6ClNO. The following is an introduction to its nature, use, preparation methods and safety information:
Nature:
-is a white to slightly yellow crystalline solid.
-It has low solubility in water, but is soluble in organic solvents.
-It is alkaline and can react with acids to form salt compounds.
Use:
-It has antibacterial properties and can be used as a drug intermediate.
-It can also be used as an intermediate for the synthesis of organic pigments and dyes.
Method:
-can be prepared by chlorination and hydrogen oxidation of quinoline. Specific steps include:
1. Reaction of quinoline with aluminum chloride (AlCl3) in an organic solvent (e. G., dichloromethane).
2. The reaction product is reacted with sodium hydroxide (NaOH) to generate calcium.
Safety Information:
-too irritant, should avoid contact with the eyes, skin and respiratory tract.
-Wear appropriate personal protective equipment such as gloves, goggles and protective masks during use.
-Ion salts may be toxic to aquatic organisms and should be avoided from entering water sources.
-During the handling process, please follow the safe operation guidelines and properly dispose of the waste in accordance with local regulations.
Nature:
-is a white to slightly yellow crystalline solid.
-It has low solubility in water, but is soluble in organic solvents.
-It is alkaline and can react with acids to form salt compounds.
Use:
-It has antibacterial properties and can be used as a drug intermediate.
-It can also be used as an intermediate for the synthesis of organic pigments and dyes.
Method:
-can be prepared by chlorination and hydrogen oxidation of quinoline. Specific steps include:
1. Reaction of quinoline with aluminum chloride (AlCl3) in an organic solvent (e. G., dichloromethane).
2. The reaction product is reacted with sodium hydroxide (NaOH) to generate calcium.
Safety Information:
-too irritant, should avoid contact with the eyes, skin and respiratory tract.
-Wear appropriate personal protective equipment such as gloves, goggles and protective masks during use.
-Ion salts may be toxic to aquatic organisms and should be avoided from entering water sources.
-During the handling process, please follow the safe operation guidelines and properly dispose of the waste in accordance with local regulations.
Last Update：2024-04-09 02:00:44
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