8-Gingerol
8-Gingerol
CAS: 23513-08-8
Molecular Formula: C19H30O4
8-Gingerol - Names and Identifiers
| Name | 8-Gingerol |
| Synonyms | 8-GINGEROL 8-Gingerol Gingerol [8] (8)-Gingerol GINGEROL [8] (s)-(+)-3-dodecanon (S)-10-Oxo-12-(3-methoxy-4-hydroxyphenyl)dodecane-8-ol (5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-dodecanone (5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)dodecan-3-one (5S)-1-(3-Methoxy-4-hydroxyphenyl)-5-hydroxydodecane-3-one (S)-(+)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-dodecanone (s)-(+)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-dodecanone 3-Dodecanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-(+)- |
| CAS | 23513-08-8 |
| InChI | InChI=1/C19H30O4/c1-3-4-5-6-7-8-16(20)14-17(21)11-9-15-10-12-18(22)19(13-15)23-2/h10,12-13,16,20,22H,3-9,11,14H2,1-2H3/t16-/m0/s1 |
| InChIKey | BCIWKKMTBRYQJU-INIZCTEOSA-N |
8-Gingerol - Physico-chemical Properties
| Molecular Formula | C19H30O4 |
| Molar Mass | 322.44 |
| Density | 1.058±0.06 g/cm3(Predicted) |
| Melting Point | 30 - 32 °C |
| Boling Point | 476.4±35.0 °C(Predicted) |
| Specific Rotation(α) | +26 (c, 0.9 in CHCl3) |
| Flash Point | 162.6°C |
| Solubility | Insoluble in water and acid, slightly soluble in alkali, easily soluble in various organic substances. |
| Vapor Presure | 6.94E-10mmHg at 25°C |
| Appearance | White crystal |
| Color | white to light yellow |
| BRN | 2059802 |
| pKa | 10.02±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.517 |
| MDL | MFCD00877794 |
| Physical and Chemical Properties | White waxy solid, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ginger, ginger. |
8-Gingerol - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 43 - May cause sensitization by skin contact |
| Safety Description | 36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| RTECS | JR4362000 |
| HS Code | 29145019 |
8-Gingerol - Reference
| Reference Show more | 1. Liang Na Sang Ya Xin Zhou Yan Liu Weihua Li Tian Ye Wang Xiang Hong. HPLC-ESI-Q-TOF-MS/MS Analysis of Gingerol Compounds in Dried Ginger [J]. Food Industry Science and Technology 2018 39(09):252-256. 2. Wang Zhirong, Li Zhili, Li Mingyan, et al. Comparison of main ingredients in Fujian fresh ginger and dried ginger. 3. Wang Zhirong, Li Zhili, Li Mingyan, Gao Zidan, Wang Baohua, Li Changhong, Li Wenxu. Comparison of Main Components in Fujian Fresh Ginger and Dried Ginger [J]. Chinese patent medicine, 2020,42(08):2230-2236. 4. [IF = 5.81] Cui Lihua et al."Chaihu Guizhi Ganjiang Decoction Ameliorates Pancreatic Fibrosis via JNK/mTOR Signaling Pathway." Front Pharmacol. 2021 Jun;0:1369 5. [IF = 3.899] su-min hu et al."8-Gingerol regulates colorectal cancer cell proliferation and migration through the EGFR/STAT/ERK pathway." Int J Oncol. 2020 Jan;56(1):390-397 |
8-Gingerol - Reference Information
| biological activity | 8-Gingerol is derived from the rhizome (Z. officinale) of ginger, has oral activity, can activate TRPV1,EC50 value is 5.0 µM. 8-Gingerol inhibits COX-2 and also inhibits the growth of H. pylori in vitro. |
| chemical properties | white waxy solid, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ginger and ginger. |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: It has a wide range of pharmacological effects such as anti-vomiting, strengthening the heart, lowering blood pressure, lowering blood lipids, anti-platelet aggregation, anti-atherosclerosis, anti-tumor, anti-oxidation, anti-inflammatory, antipyretic and analgesic. [8] Gingerol is a biologically active compound with anti-inflammatory and antioxidant activities |
Last Update：2024-04-09 21:31:57
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