80149-80-0
2-(trimethylsilyl)ethyl P-nitrophenyl carbonate
CAS: 80149-80-0
Molecular Formula: C12H17NO5Si
80149-80-0 - Names and Identifiers
| Name | 2-(trimethylsilyl)ethyl P-nitrophenyl carbonate |
| Synonyms | TEOC-ONP 4-Nitrophenyl (2-(trimethylsilyl) 2-(TRIMETHYLSILYL)ETHYL P-NITROPHENYL CARBONATE 2-(TRIMETHYLSILYL)ETHYL 4-NITROPHENYL CARBONATE 2-(trimethylsilyl)ethyl P-nitrophenyl carbonate 4-NITROPHENYL 2-(TRIMETHYLSILYL)ETHYL CARBONATE 4-Nitrophenyl 2-(trimethylsilyl)ethylecarbonate 4-Nitrophenyl 2-(trimethylsilyl)ethyl carbonate P-NITROPHENYL 2-(TRIMETHYLSILYL)ETHYL CARBONATE 4-[2-(TriMethylsilyl)ethoxycarbonyloxy]nitrobenzene TEOC-ONP 4-Nitrophenyl 2-(Trimethylsilyl)Ethyl Carbonate 2-(Trimethylsilyl)ethyl 4-nitrophenyl carbonate, TEOC-ONp Carbonic acid 4-nitrophenyl 2-(trimethylsilyl)ethyl ester |
| CAS | 80149-80-0 |
| EINECS | 279-406-7 |
| InChI | InChI=1/C12H17NO5Si/c1-19(2,3)9-8-17-12(14)18-11-6-4-10(5-7-11)13(15)16/h4-7H,8-9H2,1-3H3 |
| InChIKey | ZAQWGGKIMQIVGM-UHFFFAOYSA-N |
80149-80-0 - Physico-chemical Properties
| Molecular Formula | C12H17NO5Si |
| Molar Mass | 283.35 |
| Density | 1.147±0.06 g/cm3(Predicted) |
| Melting Point | 35-40 °C |
| Boling Point | 371.7±42.0 °C(Predicted) |
| Flash Point | 178.6°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 1.01E-05mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | Pale yellow |
| BRN | 4320585 |
| Storage Condition | 2-8°C |
| Sensitive | Moisture & Light Sensitive |
| Refractive Index | 1.503 |
80149-80-0 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8-10-21 |
| HS Code | 29319090 |
80149-80-0 - Introduction
2-(trimethylsilyl)ethyl P-nitrophenyl carbonate is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: Colorless to light yellow liquid.
-Molecular formula: C12H15NO5Si.
-Molecular weight: 281.34g/mol.
-Melting point: about 30-35 degrees Celsius.
-Boiling point: 318-320 degrees Celsius (under 760 mmHg).
-Solubility: Soluble in common organic solvents (such as alcohols, ethers, ketones, etc.).
Use:
2-(trimethylsilyl)ethyl P-nitrophenyl carbonate has a wide range of applications in organic synthesis, commonly used in the following reactions:
-As an activating reagent of carbonate, it is used to synthesize drugs such as lidocaine.
-As an N-deprotecting reagent, used to remove the amino protecting group from the compound.
-As a substitution reagent, it is used to introduce phenolic compounds into organic molecules.
Preparation Method:
The preparation method of 2-(trimethylsilyl)ethyl P-nitrophenyl carbonate is relatively simple. A common method is to react p-nitrophenol with dimethyl sulfoxide, and then react with trimethylchlorosilane and dimethyl carbonate to obtain the product.
Safety Information:
2-(trimethylsilyl)ethyl P-nitrophenyl carbonate should be stored properly, avoid contact with oxidants and strong acids, avoid inhalation, swallowing and skin contact. Pay attention to protective measures during use, such as wearing chemical goggles and gloves. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help. If swallowed or inhaled, seek medical attention immediately.
Nature:
-Appearance: Colorless to light yellow liquid.
-Molecular formula: C12H15NO5Si.
-Molecular weight: 281.34g/mol.
-Melting point: about 30-35 degrees Celsius.
-Boiling point: 318-320 degrees Celsius (under 760 mmHg).
-Solubility: Soluble in common organic solvents (such as alcohols, ethers, ketones, etc.).
Use:
2-(trimethylsilyl)ethyl P-nitrophenyl carbonate has a wide range of applications in organic synthesis, commonly used in the following reactions:
-As an activating reagent of carbonate, it is used to synthesize drugs such as lidocaine.
-As an N-deprotecting reagent, used to remove the amino protecting group from the compound.
-As a substitution reagent, it is used to introduce phenolic compounds into organic molecules.
Preparation Method:
The preparation method of 2-(trimethylsilyl)ethyl P-nitrophenyl carbonate is relatively simple. A common method is to react p-nitrophenol with dimethyl sulfoxide, and then react with trimethylchlorosilane and dimethyl carbonate to obtain the product.
Safety Information:
2-(trimethylsilyl)ethyl P-nitrophenyl carbonate should be stored properly, avoid contact with oxidants and strong acids, avoid inhalation, swallowing and skin contact. Pay attention to protective measures during use, such as wearing chemical goggles and gloves. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help. If swallowed or inhaled, seek medical attention immediately.
Last Update：2024-04-09 15:18:00
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