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81525-13-5

Forsythoside B

CAS: 81525-13-5

Molecular Formula: C34H44O19

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81525-13-5 - Names and Identifiers

Name Forsythoside B
Synonyms Forsythoside B
β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl O-D-apio-β-D-furanosyl-(1→6)-O-[6-deoxy-α-L-mannopyranosyl-(1→3)]-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
(E)-O-D-Apio-beta-D-furanosyl-(1-6)-O-[6-deoxy-alpha-L-mannopyranosyl-(1-3)]-beta-D-glucopyranoside 2-(3,4-dihydroxyphenyl)ethyl 4-[3-(3,4-dihydroxyphenyl)-2-propenoate]
[(2R,3R,4R,5R,6R)-2-[[(2R,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
(2R,3R,4R,5R,6R)-2-((((2R,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)methyl)-6-(3,4-dihydroxyphenethoxy)-5-hydroxy-4-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl (E)-3-(3,4-dihydroxyphenyl)acrylate
CAS 81525-13-5
EINECS 1592732-453-0

81525-13-5 - Physico-chemical Properties

Molecular FormulaC34H44O19
Molar Mass756.7
Density1.65
Boling Point1040.3±65.0 °C(Predicted)
Specific Rotation(α)(c, 1.37 in MeOH)-67.2；(MeOH)-93
Solubility Easily soluble in water, ethanol, and methanol, hardly soluble in ether and chloroform.
AppearanceWhite crystalline powder
ColorOff-White to Light Brown
pKa9.31±0.10(Predicted)
Storage Condition2-8°C
StabilityHygroscopic
SensitiveEasily absorbing moisture
MDLMFCD03424245
Physical and Chemical PropertiesWhite-like crystalline powder, easily soluble in methanol, from Guangdong Callicas and Phyllanthus.
In vitro study Forsythoside B concentration-dependently down-regulates the levels of TNF-α, IL-6 and high-mobility group-box 1 protein (HMGB1) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, inhibits the IκB kinase (IKK) pathway and modulated nuclear factor (NF)- κB.
In vivo study Intravenous injection of forsythoside B alone or plus imipenem reduces serum levels of TNF-α, IL-6, HMGB1, triggering receptor expressed on myeloid cells (TREM-1) and endotoxin, while the serum level of IL-10 is up-regulated and myeloperoxidase (MPO) in lung, liver and small intestine is reduced. Forsythoside B at doses higher than 8 mg/kg produces a significant neuroprotective potential in cerebral ischemia and reperfusion rats. Forsythoside B (20 mg/kg) demonstrates significant neuroprotective activity even after delayed administration at 1 h, 3 h and 5 h after cerebral ischemia and reperfusion. Forsythoside B 20 mg/kg attenuates histopathological damage as demonstrated by smaller brain infarct size and brain edema, decreased cerebral Evans blue extravasation and myeloperoxidase activity, inhibited cerebral phosphor-IκB-α and NF-κB expression. Forsythoside B shows a significant recovery in myocardial function with improvement of LVSP and +/-dp/dt(max). The myocardial infarct volume, serum levels of Tn-T, TNF-alpha and IL-6, content of MDA and MPO activity in myocardial tissue are all reduced, protein expression of HMGB1, phosphor-I kappaB-alpha and phosphor-NF-kappaB are down-regulated, while attenuate the decrease of SOD and GPx activities.

81525-13-5 - Risk and Safety

HS Code29389090

81525-13-5 - Reference

Reference
Show more
1. Hu Xiao, Li Li, Yang Yifang, etc. Caffeoyl phenylethanoid glycosides in Guangdong purple beads [J]. Chinese Journal of Traditional Chinese Medicine, 2014, 39(9):1630.
2. Li Li, Yang Yifang, Hu Xiao, etc. UFLC fingerprint of Chinese medicinal materials from Guangdong [J]. Chinese Journal of Pharmaceutical Industry, 2014, 29 (04):330-333.
3. Zhong Haiqin, Zhang Shun, Cai Ting. Effect of forsythiaside B on efflux pump activity of Klebsiella Pneumonia [J]. Chinese Journal of new drugs and Clinical Medicine, 2013(04):303-306.
4. Tan Xiangjie, Yu Fulai, Peng Yuxin, etc. Content analysis of seven components in Nuo-flower purple beads in Hainan [J]. Modern Chinese medicine, 2018, 20(002):173-178.
5. Huang Mei, Yu Fulai, Chen Zhenxia, etc. Effects of soil factors on the contents of effective components in nudiflora pall. [J]. China Pharmacy, 2018, 25 (1):2095-2099.
6. Xu Lin, Song Jian, Feng Yu, Zhang Huimin, Wang Ping. Orthogonal experimental study on extraction of Yinqiao powder with ultra-micro constant temperature [J]. Shi-zhen, National Medicine, 2020,31(09):2127-2130.
7. [IF = 3.935] Yi Tao et al."Towards the identification of alkaline phosphatase binding ligands in Li-Dan-Hua-Shi pills: A Box-Behnken design optimized affinity selection approach tandem with UHPLC-Q-TOF/MS analysis."J Pharmaceut Biomed. 2018 May;154:486
8. [IF=5.793] Fan'ge Kong et al."Forsythoside B attenuates memory impairment and neuroinflammation via inhibition on NF-κB signaling in Alzheimer's disease."J Neuroinflamm. 2020 Dec;17(1):1-15
9. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625
10. [IF=3.935] Yong-Sheng Wu et al."Chemical profiling of Callicarpa nudiflora and its effective compounds identification by compound-target network analysis."J Pharmaceut Biomed. 2020 Apr;182:113110

81525-13-5 - Reference Information

efficacy and action Forsythine glycoside B has antibacterial and anti-inflammatory effects, and is mainly used to treat wind-heat cold, carbuncle, lymph node tuberculosis, urinary tract infection and other symptoms.
biological activity Forsythine glycoside B(Forsythoside B) is a phenethylamine glycoside isolated from the leaves of the traditional Chinese medicine folk plant chakra. Forsythoside B has an effective neuroprotective effect, and has anti-inflammatory, antioxidant and antiseptic properties. Forsythoside B can inhibit TNF-alpha, IL-6, IκB and regulate NF-κB.
target TargetValue TNF-alpha () IL-6 () NF-κB () IκB ()
TargetValue
in vitro study Forsythoside B concentration-dependently down-regulates the levels of TNF-α, IL-6 and high-mobility group-box   1 protein (HMGB1) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, inhibits the IκB kinase (IKK) pathway and modulated nuclear factor (NF)- κB.
in vivo research Intravenous injection of forsythoside B alone or plus imipenem reduces serum levels of TNF-α, IL-6, HMGB1, triggering receptor expressed on myeloid cells (TREM-1) and endotoxin, while the serum level of IL-10 is up-regulated and myeloperoxidase (MPO) in lung, liver and small intestine is reduced. Forsythoside B at dos higher than 8 mg/kg produces a significant neuroprotective potential in cerebral ischemia and reperfusion rats. Forsythoside B (20 mg/kg) demonstrates significant neuroprotective activity even after delayed administration at 1 h, 3 h and 5 h after cerebral ischemia and reperfusion. Forsythoside B 20 mg/kg attenuates histopathological damage as demonstrated by smaller brain infarct size and brain edema, decreased cerebral Evans blue extravasation and myeloperoxidase activity, inhibited cerebral phosphor-IκB-α and NF-κB expression. Forsythoside B shows a significant recovery in myocardial function with improvement of LVSP and /-dp/dt(max). The myocardial infarct volume, series levels of Tn-T, TNF-alpha and IL-6, content of MDA and MPO activity in myocardial tissare all reduced, protein expression of HMGB1, phosphor-I kappaB-alpha and phosphor-NF-kappaB are down-regulated, while attenuate the decrease of SOD and GPx activities.
chemical properties white crystalline powder, soluble in methanol, derived from Guangdong purple beads and leaf beads.
use forsythioside B has anti-inflammatory and antiviral effects.
used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: antibacterial, anti-inflammatory, antipyretic, treatment of wind-heat cold, carbuncle, lymph node tuberculosis, urinary tract infection.
Last Update：2024-04-09 20:45:29
81525-13-5
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Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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Email: 3623107365@qq.com
Mobile: 18916960931
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MedChemExpress (MCE)
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Product Name: Forsythoside B (Standard) Visit Supplier Webpage Request for quotation
CAS: 81525-13-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
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Mobile: 609-228-6898
SKYRUN INDUSTRIAL CO.,LTD
Spot supply
Product Name: Forsythoside B Visit Supplier Webpage Request for quotation
CAS: 81525-13-5
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Forsythoside B Visit Supplier Webpage Request for quotation
CAS: 81525-13-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
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