83148-91-8
sophoridine
CAS: 83148-91-8;6882-68-4;641-39-4
Molecular Formula: C15H24N2O
83148-91-8 - Names and Identifiers
| Name | sophoridine |
| Synonyms | 6β-Matrine sophoridine ALLOMATRINE allomatrine 6-Allomatrine Tetrahydroisosophoramine Allomatrine 6-Allomatrine 4-(2-Biphenylyl)-1-(hydroxymethyl)-10-oxa-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione |
| CAS | 83148-91-8 6882-68-4 641-39-4 |
| InChI | InChI=1/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12-,13-,15+/m1/s1 |
83148-91-8 - Physico-chemical Properties
| Molecular Formula | C15H24N2O |
| Molar Mass | 248.36 |
| Density | 1.16 |
| Melting Point | 106-107 ºC |
| Boling Point | 396.7±31.0 °C(Predicted) |
| Specific Rotation(α) | - 63.45°(c=0.9879, water) |
| Solubility | Easily soluble in water, methanol, ethanol, carbon tetrachloride, etc. |
| Appearance | White coarse needle crystal or large prismatic crystal (petroleum ether) |
| pKa | 9.47±0.20(Predicted) |
| Storage Condition | 2-8℃ |
83148-91-8 - Reference
| Reference Show more | 1. Lu Rong, Yang, Bo, Hu, Yang, et al. Study on Preparation Technology and Evaluation of liver targeting of SOP/GL-CMCNP [J]. Journal of Harbin University of Commerce (natural sciences edition) 2020 036(003):274-280. 2. Hu Yang, Xue Hao, Wang Jinhong, Wang Hao, Xu Beilei, Sun Lipeng, Yang Bo. Preparation of sophoridine microspheres [J]. Journal of Harbin University of Commerce (natural sciences edition),2020,36(01):8-12. 3. Shi Fangyun, Feng Ping, Su Yongxia, etc. Study on acute and subacute toxicity of sophoridine [J]. Progress in animal medicine, 2020, v.41;No.323(05):48-54. 4. Wang Ling, Zhang Ting, Qian Dawei et al. Effects of volatile oil from three kinds of Chinese herbal medicines on transdermal absorption of alkaloids from Sophora flavescens [J]. Chinese Journal of Traditional Chinese Medicine, 2019 v.44(02):110-115. 5. Mingning Qiu, Fangyun Shi, Fei Dai, Runjie Song, Shuai Wang, Yanfei You, Baoyu Zhao,A reactive oxygen species activation mechanism contributes to Sophoridine-induced apoptosis in rat liver BRL-3A cells,Journal of Ethnopharmacology,Volume 213,2018,Page |
83148-91-8 - Introduction
sophoridine is a naturally occurring alkaloid, mainly found in Sophoraceae in China, such as Sophora japonica and Sophora japonica leaves. It is a white crystalline powder, soluble in water and alcohol solvents.
sophoridine has a variety of pharmacological activities, including anti-inflammatory, antioxidant, antibacterial and anti-tumor effects. Studies have shown that sophoridine may have therapeutic potential for diseases such as cardiovascular and cerebrovascular diseases, hepatitis and cancer. In addition, sophoridine can also be used as food additives, cosmetic ingredients and biological pesticides.
There are two main methods for preparing sophoridine: one is extracted from Sophoraceae plants, and the other is through chemical synthesis. Extraction methods include solvent extraction, water extraction and ultrasonic-assisted extraction. Chemical synthesis methods mainly use specific organic synthesis reactions for synthesis.
The safety information of sophoridine has not yet been fully determined, so you need to pay attention to safety during use. In laboratory or industrial production, relevant chemical safety practices must be followed, including wearing appropriate protective equipment, avoiding direct contact and inhalation. In addition, the toxicity and potential side effects of sophoridine require further research and evaluation. In medical applications, it must be used under the guidance of a doctor, and pay attention to possible allergic reactions and adverse reactions.
sophoridine has a variety of pharmacological activities, including anti-inflammatory, antioxidant, antibacterial and anti-tumor effects. Studies have shown that sophoridine may have therapeutic potential for diseases such as cardiovascular and cerebrovascular diseases, hepatitis and cancer. In addition, sophoridine can also be used as food additives, cosmetic ingredients and biological pesticides.
There are two main methods for preparing sophoridine: one is extracted from Sophoraceae plants, and the other is through chemical synthesis. Extraction methods include solvent extraction, water extraction and ultrasonic-assisted extraction. Chemical synthesis methods mainly use specific organic synthesis reactions for synthesis.
The safety information of sophoridine has not yet been fully determined, so you need to pay attention to safety during use. In laboratory or industrial production, relevant chemical safety practices must be followed, including wearing appropriate protective equipment, avoiding direct contact and inhalation. In addition, the toxicity and potential side effects of sophoridine require further research and evaluation. In medical applications, it must be used under the guidance of a doctor, and pay attention to possible allergic reactions and adverse reactions.
Last Update：2024-04-09 19:05:02
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