84468-15-5
Isoquinoline-5-sulfonyl chloride
CAS: 84468-15-5
Molecular Formula: C9H6ClNO2S
84468-15-5 - Names and Identifiers
84468-15-5 - Physico-chemical Properties
| Molecular Formula | C9H6ClNO2S |
| Molar Mass | 227.67 |
| Density | 1.483 |
| Melting Point | 173-183°C |
| Boling Point | 371.2±17.0 °C(Predicted) |
| Flash Point | 178.3℃ |
| Solubility | DMSO (Sparingly, Heated) |
| Vapor Presure | 2.23E-05mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 3.09±0.13(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Moisture Sensitive |
| Refractive Index | 1.646 |
84468-15-5 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
| HS Code | 29334900 |
84468-15-5 - Reference Information
| overview | isoquinolin-5-sulfonyl chloride is a colorless liquid and is an important intermediate for the synthesis of fasudil hydrochloride. Fasudil hydrochloride is an inhibitor of RHO kinase. By increasing the activity of myosin light chain phosphatase, it dilates blood vessels, reduces the tension of endothelial cells, improves microcirculation of brain tissue, and can antagonize anti-inflammatory factors, protect nerve against apoptosis, and promote nerve regeneration. |
Last Update：2024-04-09 15:16:38
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