84468-24-6
1-(5-ISOQUINOLINESULFONYL)PIPERAZINE, DIHYDROCHLORIDE
CAS: 84468-24-6
Molecular Formula: C13H15N3O2S
84468-24-6 - Names and Identifiers
84468-24-6 - Physico-chemical Properties
| Molecular Formula | C13H15N3O2S |
| Molar Mass | 277.34 |
| Melting Point | >240°C (dec.) |
| Solubility | DMSO, Methanol, Water |
| Appearance | Off-white lyophilized solid. |
| Color | Off-White to Pale Yellow |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| In vitro study | HA-100 inhibits MLC-kinase and PKC competitively with respect to ATP, and the K i values are 61 and 6.5 μM, respectively. |
84468-24-6 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | TM0862600 |
84468-24-6 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.606 ml | 18.028 ml | 36.057 ml |
| 5 mM | 0.721 ml | 3.606 ml | 7.211 ml |
| 10 mM | 0.361 ml | 1.803 ml | 3.606 ml |
| 5 mM | 0.072 ml | 0.361 ml | 0.721 ml |
Last Update：2024-01-02 23:10:35
84468-24-6 - Reference Information
| biological activity | HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG),cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC kinase (MLC-kinase), with IC50 values of 4, 8, 12 and 240 μM respectively. |
| target | PKC 12 μ m (IC 50 ) PKG 4 μ m (IC 50 ) PKA 8 μ m (IC 50 ) MLCK 240 μ m (IC 50 ) PKC 6.5 μ m (Ki) MLCK 61 μ m (Ki) |
| in vitro study | HA-100 inhibits MLC-kinase and PKC competitively with respect to ATP, and the K I values are 61 and 6.5 μ M, respectively. |
Last Update：2024-04-09 02:00:00
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