84677-06-5

84677-06-5 - Names and Identifiers

Name	1-(N-cbz-amino)cyclopropanecarboxylic*acid
Synonyms	1-(z-amino)cyclopropanecarboxylic acid N-Cbz-1-aminocyclopropanecarboxylic acid 1-(Cbz-amino)cyclopropanecarboxylic acid 1-(Cbz-Amino)Cyclopropanecarboxylic Acid 1-(N-cbz-amino)cyclopropanecarboxylic*acid N-Benzyloxycarbonyl-1-aminocyclopropanecarboxylic 1-Benzyloxycarbonylaminocyclopropanecarboxylic acid N-Benzyloxycarbonyl-1-aminocyclopropanecarboxylic acid 1-(Benzyloxycarbonyl-Amino)-Cyclopropyl-1-Carboxylic Acid 1-{[(benzyloxy)carbonyl]amino}cyclopropanecarboxylic acid 1-(phenylmethoxycarbonylamino)-1-cyclopropanecarboxylic acid Cyclopropanecarboxylic acid, 1-[[(phenylmethoxy)carbonyl]amino]- (9CI)
CAS	84677-06-5
EINECS	201-001-0
InChI	InChI=1/C12H13NO4/c14-10(15)12(6-7-12)13-11(16)17-8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,13,16)(H,14,15)

84677-06-5 - Physico-chemical Properties

Molecular Formula	C12H13NO4
Molar Mass	235.24
Density	1.33±0.1 g/cm3(Predicted)
Melting Point	157.0 to 161.0 °C
Boling Point	449.0±34.0 °C(Predicted)
Flash Point	225.4°C
Vapor Presure	7.55E-09mmHg at 25°C
pKa	4.02±0.20(Predicted)
Storage Condition	Sealed in dry,Store in freezer, under -20°C
Refractive Index	1.593

84677-06-5 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3

84677-06-5 - Introduction

1-(N-cbz-amino)cyclopropanecarboxylic * acid is an organic compound containing amino, cyclopropane and carboxyl groups in its chemical structure.

Nature:
1-(N-cbz-amino)cyclopropanecarboxylic * acid is a solid, usually white to yellow crystalline. It is insoluble in water at room temperature, but can be dissolved in some organic solvents, such as methanol, dimethylformamide and ether. Its melting point is about 220-230°C.

Use:
1-(N-cbz-amino)cyclopropanecarboxylic * acid is an important intermediate in organic synthesis. It can be used to synthesize various drugs, pesticides and bioactive molecules. The compound has high chemical stability and can be used as a protecting group (Cbz group) in many reactions to selectively protect the amino group. It has a wide range of applications in the synthesis, such as the synthesis of anti-tumor drugs, protein expression regulators and so on.

Preparation Method:
The preparation method of 1-(N-cbz-amino)cyclopropanecarboxylic * acid usually involves the protection of hydroxynitrile and the addition reaction of aminocyclopropane. One common method is to react an aminocyclopropane with an active formate to give 1-hydroxycyclopropane, which is then protected. A common protecting reagent is chloromethylformamide. Finally, the protecting group is removed by treatment with carbonic acid or sulfuryl chloride to give 1-(N-cbz-amino)cyclopropanecarboxylic * acid.

Safety Information:
1-(N-cbz-amino)cyclopropanecarboxylic * acid is generally considered non-toxic to humans under normal operating conditions. However, it may cause irritation to the eyes, skin and respiratory system. Therefore, during operation, care should be taken to avoid contact and use personal protective equipment, such as gloves and eye protection, if necessary. In addition, it should be operated in a well-ventilated place to avoid inhaling its dust or steam. If contact or inhalation occurs, rinse immediately with clean water and seek medical help as needed.

Last Update：2024-04-09 21:00:56