84680-75-1
Astragaloside I
CAS: 84680-75-1;84860-75-1
Molecular Formula: C45H72O16
84680-75-1 - Names and Identifiers
| Name | Astragaloside I |
| Synonyms | astragalosideⅠ ASTRAGALOSIDE I Anemarsaponin E Astragaloside I ASTRAGALOSIDE I(SH) Cyclosiversioside B Astrasieversianin IV Cyclosieversioside B Astragaloside I (Astrasieversianin IV 20,24-EPOXYCYCLOARTANE-3,16,25-TRIOL-6-O-BETA-D-GLUCOPYRANOSIDE |
| CAS | 84680-75-1 84860-75-1 |
| InChI | InChI=1/C43H68O16/c1-20(45)54-33-25(48)18-53-37(34(33)55-21(2)46)56-22-8-11-42-19-43(42)13-12-39(5)35(41(7)10-9-29(59-41)38(3,4)52)24(47)16-40(39,6)28(43)15-26(23(42)14-22)57-36-32(51)31(50)30(49)27(17-44)58-36/h22-37,44,47-52H,8-19H2,1-7H3/t22-,23?,24-,25+,26-,27+,28-,29-,30+,31-,32+,33-,34+,35-,36+,37-,39+,40-,41+,42+,43+/m0/s1 |
84680-75-1 - Physico-chemical Properties
| Molecular Formula | C45H72O16 |
| Molar Mass | 869.04 |
| Density | 1.36±0.1 g/cm3(Predicted) |
| Melting Point | 246-250°C |
| Boling Point | 911.8±65.0 °C(Predicted) |
| Specific Rotation(α) | (c, 0.64 in MeOH)+12.7;(c, 0.88 in MeOH)+10.7 |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Appearance | White crystalline powder |
| Color | White to Off-White |
| pKa | 12.87±0.70(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.603 |
| MDL | MFCD30478908 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Astragalus. |
| In vitro study | Astragaloside I (10-40 μM) upregulates the express of β-catenin, Runx2, BGP and OPG, RANKL (osteogenesis marker genes) in MC3T3-E1 cells. Western Blot Analysis. Cell Line: MC3T3-E1 cells. Concentration: 0, 10, 20, 40 μM. Incubation Time: 5 days. Result: Stimulated the expression of β-catenin and Runx2. Cell Cytotoxicity Assay. Cell Line: MC3T3-E1 cells. Concentration: 0, 10, 20, 40 μM. Incubation Time: 1, 3 or 6 days (The media was changed every 2 days). Result: No obvious cytotoxic effect was observed in the MC3T3-E1 cells. |
84680-75-1 - Reference
| Reference Show more | 1. Right Yan, Ma Tianzhu, Wang Xiaoyang. Extraction and activity detection of whitening components in radix glycyrrhizae-radix astragali group prescription [J]. Contemporary Chemical Engineering, 2019(9). 2. Zhang Yunming, Zhang Liying, Liu Yongqi, Zhang Yuemei, Li Yangyang, Feng Caiqin, Zhang Lixin, He Jinpeng, Feng Xiu, Hua Junrui. Protective effect of Astragaloside on gene damage of bone marrow mesenchymal stem cells induced by X-Ray [J]. Chinese Journal of Clinical Pharmacology, 2021,37(03):280-283. 3. Li Yangyang, Zhang Yiming, Wei kongxi, Zhou Ting, He Jinpeng, Ding Nan, Zhou Gucheng, Shi tongfan, Ke Yicheng, cow fan, Liu Yongqi, Zhang Liying. Comparative study on the protective effects of different effective components of astragalus on DNA damage of BMSCs induced by ionizing radiation [J]. China Pharmacy, 2020,31(24):2987-2992. 4. Zhang, Yuping, et al. "Integration of magnetic solid phase fishing and off-line two-dimensional high-performance liquid chromatography-diode array detector-mass spectroscopy for screening> 5. Yuping Zhang, Shuyun Shi, Junfang Guo, Qingping You, Deshan Feng, On-line surface plasmon resonance-high performance liquid chromatography-tandem mass spectrometry for analysis of human serum albumin binders from Radix Astragali, Journal of Chromatography 6. [IF=7.514] Yuping Zhang et al."Integration of magnetic solid phase fishing and off-line two-dimensional high-performance liquid chromatography-diode array detector-mass spectrometry for screening and identification of human serum albumin binders from Radix Astragali 7. [IF=4.759] Yuping Zhang et al."On-line surface plasmon resonance-high performance liquid chromatography-tandem mass spectrometry for analysis of human serum albumin binders from Radix Astragali."J Chromatogr A. 2013 Jun;1293:92 8. [IF=5.81] Gu Junfei et al."Standardized Astragalus Mongholicus Bunge-Curcuma Aromatica Salisb. Extract Efficiently Suppresses Colon Cancer Progression Through Gut Microbiota Modification in CT26-Bearing Mice."Front Pharmacol. 2021 Aug;0:2278 9. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal-Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321-5328 |
84680-75-1 - Reference Information
| overview | astragaloside I is extracted and refined from leguminous plant astragalus mongholicus and is white crystalline powder. At present, astragalus is mostly used in the treatment of senile dementia in the form of drug prescriptions, and some studies have found that astragalus polysaccharide can improve the learning and memory of rats. |
| biological activity | Astragaloside I is a natural compound isolated from astragalus. Astragaloside I can stimulate osteoblast differentiation through Wnt/β-catenin signaling pathway and has osteogenic activity. |
| in vitro study | Astragaloside I (10-40 μ m) upregulates the express of beta-catenin, runx2, bgp and opg, rankl (osteogenesis marker genes) in MC3T3-E1 cells. Western blot Analysis. cell line: MC3T3-E1 cells. Concentration: 0, 10, 20, 40 μ m. Incubation time: 5 days. result: Stimulated the expression of beta-catenin and runx2. cell Cytotoxicity Assay. cell line: MC3T3-E1 cells. Concentration: 0, 10, 20, 40 μ m. Incubation time: 1, 3 or 6 days (the media was changed every 2 days). result: no obvious cytotoxic effect was observed in the MC3T3-E1 cells. |
| Cell Line: | MC3T3-E1 cells. MC3T3-E1 cells. |
| Concentration: | 0, 10, 20, 40 μM. 0, 10, 20, 40 μM. |
| Incubation Time: | 5 days. 1, 3 or 6 days (The media was changed every 2 days). |
| Result: | Stimulated the expression of β-catenin and runx2. no obvious cytotoxic effect was observed in the MC3T3-E1 cells. |
| chemical properties | white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from astragalus membranaceus. |
| use | astragaloside I has the effects of improving heart and lung, dilating blood vessels and lowering blood pressure. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: It has the effects of protecting the heart, strengthening the heart, anti-gastric ulcer, inhibiting collagen proliferation, improving hemorheology, anti-aging, immunomodulatory effects on the body, protecting the liver, antibacterial and anti-inflammatory, lowering blood pressure, analgesia and sedation, diuresis, Promote the secretion of insulin and other effects. |
Last Update：2024-04-09 21:48:26
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View History
84680-75-1
18944-77-9
Thifensulfuron
Sec. Alkane sulphonate-Na salt
7803-58-9
ETHYL SULFONAMIDE
Nickel Hydroxide
yttrium
TH287
Octadecanoic acid, 1-methylethyl ester
18944-77-9
Thifensulfuron
Sec. Alkane sulphonate-Na salt
7803-58-9
ETHYL SULFONAMIDE
Nickel Hydroxide
yttrium
TH287
Octadecanoic acid, 1-methylethyl ester