849062-37-9
3-Bromo-5-fluorophenylboronic acid
CAS: 849062-37-9
Molecular Formula: C6H5BBrFO2
849062-37-9 - Names and Identifiers
| Name | 3-Bromo-5-fluorophenylboronic acid |
| Synonyms | 3-Bromo-5-fluorophenylboronic acid 3-Bromo-5-fluorobenzeneboronic acid 3-BROMO-5-FLUOROBENZENEBORONIC ACID 95 Boronic acid, B-(3-bromo-5-fluorophenyl)- |
| CAS | 849062-37-9 |
| InChI | InChI=1/C6H5BBrFO2/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,10-11H |
849062-37-9 - Physico-chemical Properties
| Molecular Formula | C6H5BBrFO2 |
| Molar Mass | 218.82 |
| Density | 1.75±0.1 g/cm3(Predicted) |
| Melting Point | >300 |
| Boling Point | 329.0±52.0 °C(Predicted) |
| Flash Point | 152.795°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 6.52±0.10(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | 1.572 |
849062-37-9 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| Hazard Note | Irritant/Keep Cold |
849062-37-9 - Introduction
Acid is an organic compound with the chemical formula C6H5BBrFO2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White or off-white solid
-Melting point: about 132°C
-Solubility: Soluble in most organic solvents such as ethanol, methanol and dichloromethane
Use:
-acid is an important organic synthesis intermediate, which is often used in Suzuki-Miyaura reactions in organic synthesis reactions. This reaction typically reacts the lithium acid with an organic halide or ethynyl bromide to produce the target compound, which enables the construction of the C- C bond.
-or acid can also be used to prepare other drugs, pesticides and functional compounds.
Preparation Method:
The acid is usually prepared by the following two methods:
1. 3-bromo-5-fluorobenzene reacts with tributyl hydroborate under alkaline conditions, and then acidifies to obtain the target product.
2. hydrogenate the acid derivative under alkaline conditions, and then acidify to obtain the target product.
Safety Information:
-the toxicity of acid is low, but it is still necessary to pay attention to safe operation measures, such as protective gloves and glasses.
-Avoid inhaling, chewing or exposing it to the skin or eyes, and avoid inhaling its dust.
-Ensure well-ventilated laboratory conditions during use, and handle and store in accordance with safe operating procedures.
Nature:
-Appearance: White or off-white solid
-Melting point: about 132°C
-Solubility: Soluble in most organic solvents such as ethanol, methanol and dichloromethane
Use:
-acid is an important organic synthesis intermediate, which is often used in Suzuki-Miyaura reactions in organic synthesis reactions. This reaction typically reacts the lithium acid with an organic halide or ethynyl bromide to produce the target compound, which enables the construction of the C- C bond.
-or acid can also be used to prepare other drugs, pesticides and functional compounds.
Preparation Method:
The acid is usually prepared by the following two methods:
1. 3-bromo-5-fluorobenzene reacts with tributyl hydroborate under alkaline conditions, and then acidifies to obtain the target product.
2. hydrogenate the acid derivative under alkaline conditions, and then acidify to obtain the target product.
Safety Information:
-the toxicity of acid is low, but it is still necessary to pay attention to safe operation measures, such as protective gloves and glasses.
-Avoid inhaling, chewing or exposing it to the skin or eyes, and avoid inhaling its dust.
-Ensure well-ventilated laboratory conditions during use, and handle and store in accordance with safe operating procedures.
Last Update：2024-04-09 02:00:48
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CAS: 849062-37-9
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