873798-09-5

873798-09-5 - Names and Identifiers

Name	2-(7-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate
Synonyms	TATU 2-(7-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate O-(7-Azabenzotriazole-1-yl)-N,N,N',N'-tetraMethyluroniuM tetrafluoroborat O-(7-Azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate TATU (O-(7-AZABENZOTRIAZOL-1-YL)-N,N,N'',N''-TETRAMETHYLURONIUM TETRAFLUOROBORATE) 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide tetrafluoroborate [bis(dimethylamino)methylidene](3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxonium tetrafluoroborate
CAS	873798-09-5
EINECS	805-247-5
InChI	InChI=1/C10H15N6O.BF4/c1-14(2)10(15(3)4)17-16-9-8(12-13-16)6-5-7-11-9;2-1(3,4)5/h5-7H,1-4H3;/q+1;-1

873798-09-5 - Physico-chemical Properties

Molecular Formula	C10H15BF4N6O
Molar Mass	322.07
Melting Point	184 °C(dec.)
Appearance	White powder
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

873798-09-5 - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R65 - Harmful: May cause lung damage if swallowed
Safety Description	S20 - When using, do not eat or drink. S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	1759
HS Code	29339990
Hazard Class	8
Packing Group	III

873798-09-5 - Introduction

2-(7-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyl tetrafluoroborate, commonly abbreviated as TBTU, is an organic compound. The following is a description of some of the properties, uses, formulation and safety information of TBTU:

Nature:
TBTU is a colorless crystalline solid and is a commonly used activator in chemical reactions. It is stable at room temperature, soluble in organic solvents such as dimethylthionamide (DMSO) and N,N-dimethylacetamide (DMF), but almost insoluble in water.

Use:
TBTU is commonly used as an activator of amino acids and polypeptides to promote acylation reactions. TBTU can effectively introduce amino acids or amino groups when synthesizing peptide chains or other organic compounds. It has a wide range of applications in solid phase synthesis and liquid phase synthesis.

Preparation Method:
The preparation of TBTU usually involves the following steps:
1. Reaction with tetramethylurea: tetramethylurea is reacted with trifluoroboric acid to obtain tetramethylurea tetrafluoroborate.
2. reaction with 7-azabenzotriazole: tetramethylurea tetrafluoroborate reacts with 7-azabenzotriazole to generate TBTU.

Safety Information:
TBTU is relatively stable under normal conditions, but contact with skin and eyes should still be avoided. Wear appropriate protective gloves and goggles during operation. The operation needs to be carried out in a well-ventilated area to prevent inhalation and swallowing. If inhaled or taken by mistake, seek medical attention immediately.

Last Update：2024-04-09 02:00:48

Shanghai Macklin Biochemical Co., Ltd

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