876345-13-0
Boc-NH-PEG(3)-COOH
CAS: 876345-13-0
Molecular Formula: C15H29NO8
876345-13-0 - Names and Identifiers
876345-13-0 - Physico-chemical Properties
| Molecular Formula | C15H29NO8 |
| Molar Mass | 351.39 |
| Density | 1.138±0.06 g/cm3(Predicted) |
| Boling Point | 493.6±40.0 °C(Predicted) |
| pKa | 3.39±0.10(Predicted) |
| Storage Condition | -20°C |
| In vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
876345-13-0 - Reference Information
| biological activity | Boc-NH-PEG4-CH2COOH is a degradable ADC linker, which is used to synthesize degradable antibody conjugated drugs (ADC) ADC linker. Boc-NH-PEG4-CH2COOH is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis. |
| target | Cleavable Alkyl/ether PEGs |
| in vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
Last Update：2024-04-09 21:21:28
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