882663-88-9
AMG-47a
CAS: 882663-88-9
Molecular Formula: C29H28F3N5O2
882663-88-9 - Names and Identifiers
882663-88-9 - Physico-chemical Properties
| Molecular Formula | C29H28F3N5O2 |
| Molar Mass | 535.56 |
| Density | 1.324 |
| pKa | 13.23±0.70(Predicted) |
| Storage Condition | 2-8 ℃, dark |
882663-88-9 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.867 ml | 9.336 ml | 18.672 ml |
| 5 mM | 0.373 ml | 1.867 ml | 3.734 ml |
| 10 mM | 0.187 ml | 0.934 ml | 1.867 ml |
| 5 mM | 0.037 ml | 0.187 ml | 0.373 ml |
Last Update：2024-01-02 23:10:35
882663-88-9 - Reference Information
| biological activity | AMG-47a is an effective and non-selective Lck kinase inhibitor, IC50 is 3.4 uM, it can also inhibit T cell proliferation. AMG-47a exhibited 11 mg/kg anti-inflammatory activity (ED50) during anti-CD3-induced production of mouse interleukin-2 (IL-2). |
| target | TargetValue LCK (Cell-free say) 3.4 μM |
| Target | Value |
| LCK (Cell-free assay) | 3.4 μM |
Last Update：2024-04-09 15:16:36
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View History
882663-88-9
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