88495-54-9
L-1-Boc-Nipecotic acid
CAS: 88495-54-9
Molecular Formula: C11H19NO4
88495-54-9 - Names and Identifiers
88495-54-9 - Physico-chemical Properties
| Molecular Formula | C11H19NO4 |
| Molar Mass | 229.27 |
| Density | 1.164±0.06 g/cm3(Predicted) |
| Melting Point | 159-162°C(lit.) |
| Boling Point | 353.2±35.0 °C(Predicted) |
| Flash Point | 167.4°C |
| Vapor Presure | 6.15E-06mmHg at 25°C |
| pKa | 4.49±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.496 |
| MDL | MFCD02179172 |
88495-54-9 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R50 - Very Toxic to aquatic organisms |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
88495-54-9 - Reference Information
| Introduction | piperidine N-Boc-(S)-3-carboxylate is solid at normal temperature and pressure, it can be used as a pharmaceutical intermediate in the manufacture of local anesthetics, analgesics, fungicides, wetting agents, epoxy resin curing agents, rubber vulcanization accelerators and the like. |
| Use | N-Boc-(S)-3-carboxylic acid piperidine can be used for the preparation of local anesthetics, analgesics, fungicides, wetting agents, etc. In organic synthesis conversion, the carboxyl group in the structure can be reduced to hydroxyl group by borane tetrahydrofuran solution, and the carboxyl group can also be converted to Ester group or amide group. |
| preparation method | triethylamine (1.92 ML, 13.66 mmol, 1.2 equiv) was added at 0°C. And Boc2O(3.48 ML, 15.93 mmol, 1.4 equiv) was added to a solution of nipaginic acid (1.5g, 11.38 mmol, 1 equiv) in methanol (44 ml), the resulting reaction mixture was warmed to room temperature and the mixture was stirred at room temperature overnight. To the mixture was added a mixed solution of dichloromethane and water = 5:1(60 ml), and then hydrochloric acid (1N) was added to adjust the pH of the reaction system to pH = 3. The aqueous phase was extracted with dichloromethane, the combined organic phases were dried over anhydrous magnesium sulfate, the mixture was filtered to remove magnesium sulfate solids, and the filtrate was concentrated under reduced pressure. The residue was separated and purified by silica gel column chromatography (dichloromethane to methanol 95:5 to 85:15) to give piperidine N-Boc-(S)-3-carboxylate. Figure N-Boc-(S)-piperidine -3-carboxylate synthesis |
Last Update：2024-04-09 15:16:53
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