| Molecular Formula | C30H31F3N8O |
| Molar Mass | 576.62 |
| Density | 1.36 |
| Melting Point | >166°C (dec.) |
| Solubility | DMSO, Methanol |
| Appearance | Solid |
| Color | Yellow |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Physical and Chemical Properties | Appearance: white or white-like crystalline powder Dissolution: dissolved in DMSO (up to 100 mM) Preservation: 3 years -20 ℃ powder Figure 1 shows bafitinib |
| Use | Bafetinib (INNO-406) is an effective, selective, Bcr-Abl/Lyn dual inhibitor with IC50 of 5.8 nM/19 nM. It has no inhibitory effect on phosphorylation of T315I mutant, and has a slightly weaker effect on PDGFR and c-Kit. |
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.734 ml | 8.671 ml | 17.342 ml |
| 5 mM | 0.347 ml | 1.734 ml | 3.468 ml |
| 10 mM | 0.173 ml | 0.867 ml | 1.734 ml |
| 5 mM | 0.035 ml | 0.173 ml | 0.347 ml |