894787-30-5
ST 2825
CAS: 894787-30-5
Molecular Formula: C27H28Cl2N4O5S
894787-30-5 - Names and Identifiers
894787-30-5 - Physico-chemical Properties
| Molecular Formula | C27H28Cl2N4O5S |
| Molar Mass | 591.51 |
| Density | 1.51±0.1 g/cm3(Predicted) |
| Boling Point | 939.0±65.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 12.86±0.70(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | ST2825 blocks IL-1R/TLR signaling by interfering with MyD88 homodimerization. ST2825 inhibits this interaction in a concentration-dependent manner with ~40% inhibition of dimerization at 5 μM ST2825 and 80% inhibition at 10 μM ST2825. |
| In vivo study | ST2825 dose-dependently inhibits IL-1β-induced production of IL-6 in treated mice after oral administration. The animals are administered orally with the appropriate vehicles or ST2825 at doses ranging from 50 to 200 mg/kg, 5 min prior to i.p. injection with 20 μg/kg IL-1β. ST2825 exertes a significant inhibition of IL-1β-stimulated production of IL-6 at 100 and 200 mg/kg. |
894787-30-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.691 ml | 8.453 ml | 16.906 ml |
| 5 mM | 0.338 ml | 1.691 ml | 3.381 ml |
| 10 mM | 0.169 ml | 0.845 ml | 1.691 ml |
| 5 mM | 0.034 ml | 0.169 ml | 0.338 ml |
Last Update：2024-01-02 23:10:35
894787-30-5 - Reference Information
| biological activity | ST 2825 is a specific MyD88 dimerization inhibitor. ST 2825 interferes with the recruitment of IRAK1 and IRAK4 by MyD88 and inhibits IL-1β-mediated NF-κB transcriptional activity. |
| Target | MyD88 |
| in vitro study | ST2825 blocks IL-1R/TLR signaling by interposing with MyD88 homodiderivation. ST2825 indications this interaction in a concentration-dependent manner with ~ 40% inhibition of differentiation at 5 μm ST2825 and 80% inhibition at 10 μm ST2825. |
| in vivo study | ST2825 dose-dependently inhibits IL-1β-induced production of IL-6 in treated mice after oral administration. The animals are administered orally with the appropriate vehicles or ST2825 at orders ranging from 50 to 200 mg/kg, 5 min prior to I .p. injection with 20 μg/kg IL-1β. ST2825 exertes a significant inhibition of IL-1β-stimulated production of IL-6 at 100 and 200 mg/kg. |
Last Update：2024-04-09 21:01:54
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Multiple SpecificationsSpot supply
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Email: Int06@meryer.com
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Product Name: ST 2825 Visit Supplier Webpage Request for quotationCAS: 894787-30-5
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Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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Spot supply
Product Name: ST 2825 Visit Supplier Webpage Request for quotationCAS: 894787-30-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: ST 2825 Visit Supplier Webpage Request for quotation
CAS: 894787-30-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 894787-30-5
Tel: 18301782025
Email: 3008007409@qq.com
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View History
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