9000-81-1
Anticholinesterase
CAS: 9000-81-1
Molecular Formula:
9000-81-1 - Names and Identifiers
9000-81-1 - Physico-chemical Properties
| Solubility | H2O: 1 mg/mL |
| Appearance | powder |
| Color | slightly yellow |
| Storage Condition | -20°C |
| MDL | MFCD00081268 |
9000-81-1 - Risk and Safety
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| Toxicity | The inhibition of AChE by these anticholinesterases leads to an accumulation of endogenous ACh, and thus results in hyperactivation of cholinergic receptors. Signs of acute poisoning can include irritability, tremors, convulsions, and predominately parasympathetic effects, with death usually the result of respiratory failure. Since AChE is contained in erythrocytes, the assay of erythrocyte AChE activity can be used as a diagnostic tool to assess exposure to organophosphorus anticholinesterases. |
9000-81-1 - Introduction
Under certain conditions, organophosphorus and carbamates have an inhibitory effect on the normal function of cholinase, and the inhibition rate is proportional to the concentration of pesticide. Under normal circumstances, the enzyme catalyzes the hydrolysis of the neuroconductive metabolite (acetylcholine), and its hydrolysate The product reacts with the developer to produce a yellow substance. The change value of absorbance with time is measured by a spectrophotometer to calculate the inhibition rate. The presence of organophosphorus and carbamate pesticides in the product can be measured by the inhibition rate.
Last Update：2022-10-16 17:31:02
9000-81-1 - Trait
Off-white or brown powder.
Last Update：2023-08-16 21:32:38
9000-81-1 - Vitality definition
At 37 C, 0.1mol/L pH = 8.0 phosphate buffer conditions, 1umol per minute decomposition of thioacetylcholine iodide (ATCI) enzyme amount for an acetylcholinesterase activity unit.
Last Update：2023-08-16 21:32:38
9000-81-1 - Source
From the head of a fly that is extremely sensitive to pesticides.
Last Update：2023-08-16 21:32:38
9000-81-1 - Vitality
≥200units/g protein
Last Update：2023-08-16 21:32:38
9000-81-1 - Uses and synthesis methods
overview
Acetylcholine and acetylcholinesterase are a pair of chemicals that maintain normal physiological functions between nerves and muscle junctions, also known as mediators or transmitters. Acetylcholine is an action substance, which transmits nerve impulses to generate action potentials; while cholinesterase is an antagonist, which hydrolyzes acetylcholine to remove it. In other words, after acting on the receptor, the acetylcholine released by the nerve fiber endings is quickly hydrolyzed and cleared by the specific cholinesterase. This pair of chemicals jointly maintains the balance of physiological functions transmitted by the neuromuscular junction. An abnormality in a certain link may occur. Clinical use of anticholinesterase drugs such as neostigmine sulfate and pyridostigmine bromide to treat myasthenia gravis, that is, according to this principle, neutralizes or eliminates the antagonist cholinesterase, and the action substance acetylcholine can be extended Its efficacy, thereby slowing down its transmission dysfunction, and temporarily alleviating clinical symptoms.
biotech grade
Biotechnology grade acetylcholinesterase
vitality: ≥ 200units/g protein
definition of enzyme activity unit: under the condition of 37 ℃,0.1mol/L pH = 8.0 phosphate buffer, the amount of enzyme that decomposes 1umol iodide thioacetylcholine (ATCI) per minute is an acetylcholinesterase activity unit
Character: white-like or brown powder. From the head of a fly that is extremely sensitive to pesticides. Under certain conditions, organophosphorus and carbamates have an inhibitory effect on the normal function of cholinase, and the inhibition rate is proportional to the concentration of pesticide. Under normal circumstances, the enzyme catalyzes the hydrolysis of the neuroconductive metabolite (acetylcholine), and its hydrolysate The product reacts with the developer to produce a yellow substance. The change value of absorbance with time is measured by a spectrophotometer to calculate the inhibition rate. The presence of organophosphorus and carbamate pesticides in the product can be measured by the inhibition rate.
history of use
On the eve of World War II, German chemists synthesized the first nerve agent for the first time, which exerts lethality by combining with acetylcholinesterase (AChE). Acetylcholinesterase (AChE) is an enzyme that decomposes the neurotransmitter acetylcholine after it is released. It is one of the most efficient enzymes known. A single AChE molecule can hydrolyze 600 per minute. 000 acetylcholine molecules. The gene encoding AChE is located on our chromosome 7.
The nerve agent can enter the active center of AChE stenosis and form a stable covalent bond with a serine residue, so that AChE cannot perform the function of degrading acetylcholine. When a large amount of acetylcholine is accumulated at the synapse, various tissues of the body regulated by acetylcholine (mainly various muscles, and other studies have shown that acetylcholine also plays a role when the brain is in mild tension and concentration) will have their functions. Different degrees of disorder, the further effect is that the brain's regulation of breathing will stop. The victim will have spasms, syncope and suffocation and eventually die.
Last Update：2024-04-10 22:29:15
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Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Featured ProductsMultiple SpecificationsSpot supply
Product Name: ACHE；Acetylcholinesterase；Acetylcholine acetylhydrolase；Cholinesterase, Acetyl Visit Supplier Webpage Request for quotationCAS: 9000-81-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: Acetylcholinesterase Request for quotationCAS: 9000-81-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Acetylcholinesterase Visit Supplier Webpage Request for quotationCAS: 9000-81-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: ACHE; EC 3.1.1.7 Visit Supplier Webpage Request for quotationCAS: 9000-81-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
View History
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