92307-52-3
Corticotropin Releasing Factor bovine
CAS: 92307-52-3
Molecular Formula: C206H340N60O63S
92307-52-3 - Names and Identifiers
92307-52-3 - Physico-chemical Properties
| Molecular Formula | C206H340N60O63S |
| Molar Mass | 4697.333 |
| Storage Condition | −20°C |
| MDL | MFCD00081537 |
| In vitro study | CRF, bovine is a potent agonist of CRF receptor, and displaces [ 125 I-Tyr]ovine CRF with a K i of 3.52 nM. CRF shows pEC 50 s of 11.16, 8.53 and 8.70 for human CRF 1 , human CRF 2 and rat CRF 2α . CRF is released from hypothalamic-pituitary-adrenal (HPA) axis induced by stress, and leads to production of glucocorticoids which down regulate immune responses. CRF also has proinflammatory effects. CRF affects brain microvessel endothelial cells (BMEC) structure or function, CRF (100 nM) significantly increases cAMP in BMEC. |
92307-52-3 - Risk and Safety
| WGK Germany | 3 |
92307-52-3 - Reference
| Reference Show more | 1. Zhao Hui, Lin Lin, Zhu Yangchun, etc. Effect of Bushen Tongdu capsule on hypothalamus-pituitary-adrenal axis in rats with collagen-induced arthritis [J]. Journal of Hubei University of Traditional Chinese Medicine, 2015, 17(1):13-15. |
92307-52-3 - Reference Information
| biological activity | CRF, bovine is an effective CRF receptor agonist that can replace [125I-Tyr]ovine CRF with a Ki value of 3.52 nM. |
| target | Ki: 3.52 nM (CRF receptor) |
| in vitro study | CRF, bovine is a potent agonist of CRF receptor, and displaces [ 125 I-Tyr]ovine CRF with a K I of 3.52 nM. CRF shows pEC 50 s of 11.16, 8.53 and 8.70 for human CRF 1 , human CRF 2 and rat CRF 2 α . CRF is released from hypothalamic-pituitary-adrenal (HPA) axis induced by stress, and led to production of glucocorticoids which down regulate immune responses. CRF also has proinflammatory effects. CRF affects brain microvessel endothelial cells (BMEC) structure or function, CRF (100 nM) significantly increases cAMP in BMEC. |
Last Update：2024-04-09 20:52:54
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View History
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377727-87-2
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