98619-25-1
Schisandrone
CAS: 98619-25-1
Molecular Formula: C21H24O5
98619-25-1 - Names and Identifiers
| Name | Schisandrone |
| Synonyms | Schisandrone Arisantetralone C 1(2H)-Naphthalenone, 4-(3,4-dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-2,3-dimethyl-, (2S,3S,4R)- |
| CAS | 98619-25-1 |
98619-25-1 - Physico-chemical Properties
| Molecular Formula | C21H24O5 |
| Molar Mass | 356.41 |
| Density | 1.159±0.06 g/cm3(Predicted) |
| Melting Point | 180-181℃ |
| Boling Point | 508.2±50.0 °C(Predicted) |
| Solubility | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Appearance | Cryst |
| pKa | 9.38±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD21333770 |
98619-25-1 - Reference Information
| overview | schisandra ketone (Sehisandrone) is also called schisandra ketone. it is the main component of the effective drug of schisandra chinensis. it is a kind of lignans with 4-phenyltetrahydrocai skeleton, which can be extracted from schisandra chinensis. Schisandra ketone has a strong antioxidant effect. Data show that its antioxidant effect is stronger than vitamins, and it also has an inhibitory effect on brain microsomal lipid peroxidation, and can protect cells under reactive oxygen stress. It can reduce the damage of neurons. |
| basic overview | Chinese name: schisandrone English name: Sehisandrone molecular formula: C21H24O5 molecular weight: 356.412 CAS No:98619-25-1 |
| Main research and application | Many studies have shown that schisandrone has a good effect on the treatment of Alzheimer's disease (AD), and neuronal extracellular β-amyloid protein (Aβ) Deposition, forming the center of senile plaques (SPs), causing neuronal damage, is an important neuropathological feature of Alzheimer's disease (AD). through experiments, it can be found that schisandrin and Aβ treated with "aging" for 3 days jointly act on rat hippocampal neurons for 48 h, and then use dual-wavelength fluorescent indicator Fura-2/AM to determine, it is found that neuron [Ca2] I is significantly lower than that of neuron cells treated with Aβ alone, the results showed that schisandrin had a certain blocking effect on the increase of intracellular Ca2 + induced by Aβ, and had a certain protective effect on the oxidative damage of neuronal cells caused by β-AP. Therefore, schisandrone is a potential new drug for the treatment of AD. |
| main references | 1. Yu Fang et al.. effects of schisandrin on learning and memory function and expression of nuclear factor kappa B and inducible nitric oxide synthase in hippocampus of Alzheimer's disease-like rats [J],2007,28(12):1351. 2. Zhang Ming et al.. Experimental Study on the Protection of Schisandrin against Ketamine Injury in Rat Cortical Neurons [J],2012,21(3):266. 3. Zhu Jiaqi et al.. Protective Effect of Schisandrin on Neuron Stress Injury Caused by β Amyloid Protein [J],2007,28(9):1015-1016. 4. Zhu Jiaqi et al. Effect of Schisandrin on β-amyloid-induced changes in free calcium concentration in rat hippocampal neurons [J],2005,28(9):791-792. |
| biological activity | Schisandrone is a 4-aryltetrahydrofuran lignans isolated from dried fruits of Schisandra chinensis. |
Last Update：2024-04-09 21:54:55
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