AC-5216
AC-5216
CAS: 226954-04-7
Molecular Formula: C23H23N5O2
AC-5216 - Names and Identifiers
AC-5216 - Physico-chemical Properties
| Molecular Formula | C23H23N5O2 |
| Molar Mass | 401.46 |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | 2-8°C |
| In vivo study | Emapunil (AC-5216, 0.1-3, 0.003-0.01 and 0.01-0.3 mg/kg, p.o.) produces anti-anxiety effects in the Vogel-type conflict test in rats, and in the light/dark box and social interaction tests in mice. Emapunil (AC-5216, 3-30 mg/kg, p.o.) reduces the immobility time, and this effect was blocked by PK11195. Emapunil (AC-5216, 1-100 mg/kg, p.o.) produces no distinct change in the rat electroencephalogram. Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) causes significant suppression of the enhanced anxiety and contextual fear induced in post-TDS rats. Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) alleviates the enhanced anxiety and fear response in a time-dependent sensitization (TDS) procedure, a rat PTSD animal model. Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) reverses the increased plasma glucose (PG) and decreased insulin (INS) in HFD-STZ rats. Animal Model: Rats. Dosage: 0.1-3 mg/kg. Administration: P.O.. Result: Significantly increased the number of shocks that rats received. Significantly increased the time spent in the light compartment but only slightly increased that time at 0.03 mg/kg, p.o. (P<0.1). |
AC-5216 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.491 ml | 12.454 ml | 24.909 ml |
| 5 mM | 0.498 ml | 2.491 ml | 4.982 ml |
| 10 mM | 0.249 ml | 1.245 ml | 2.491 ml |
| 5 mM | 0.05 ml | 0.249 ml | 0.498 ml |
Last Update：2024-01-02 23:10:35
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