ACID(RG)
PODOPHYLLUM RESIN
CAS: 9000-55-9
Molecular Formula: C88H92O34
ACID(RG) - Names and Identifiers
ACID(RG) - Physico-chemical Properties
| Molecular Formula | C88H92O34 |
| Molar Mass | 1693.65168 |
| Appearance | powder |
| Color | brown |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Use | The main components of podophyllotoxin are podophyllotoxin, α-lipotoxin, β-lipotoxin, four components of lignans. It can inhibit wart Virus DNA mitosis and synthesis, kill Virus, and corrosion, keratolytic effect. |
ACID(RG) - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | R61 - May cause harm to the unborn child R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. R34 - Causes burns |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | TP8925000 |
ACID(RG) - Experimental observation on the effect of podophyllol resin and podophyllol lipid on transplanted tumor in mice
From HowNet
Author:
Wang Dawei ,< a href = "https://xueshu.baidu.com/s?wd=author: (Zhang Peiyi) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Zhang Peiyi ,< a href = "https://xueshu.baidu.com/s?wd=author: (Liang Zhongdong) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Liang Zhongdong , Meng Fumin
Summary:
this paper reports that the extracts of peach seven from ma zhangshan, Gansu province: podophyllum resin and podophylloin are used for intraperitoneal injection of mice inoculated with transplanted tumors: ehrlich ascites cancer, sarcoma 180, liver cancer and cervical cancer 14. it is concluded that podophylloin resin and podophylloin have inhibitory effects on these tumors, and the inhibition rates are 27-
keywords:
Taoerqi podophyllum resin podophyllin transplanted tumor a href = "https://xueshu.baidu.com/s?wd=抑制作用&tn=SE_baiduxueshu_c1gjeupa&ie=utf-8" target = "_blank"> Inhibition
cited:
Year:
1984
Last Update：2024-01-02 23:10:35
ACID(RG) - 1H-NMR and Computer Simulation Study on Dehydration Process of Podophyllin
From Wanfang
Author:
He Yong ,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(8 a06f0a4c262f71e) author:(Yang Liangyan)" target = "_blank"> Yang Liangyan ,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(a82e8b12c354ce88) author:(Hua Danyu)" target = "_blank"> Hua Danyu/a >,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(aef79502c23edbb5) author:(Ma Weiyong)" target = "_blank"> Ma Weiyong ,< a href = "https://xueshu.baidu.com/usercenter/data/author?cmd=authoruri&wd=authoruri:(c178ecb4c3aad9b3) author:(Zhang Chunnian)" target = "_blank"> Zhang Chunnian
Summary:
The dehydration of podophyllol can only obtain β-unsaturated bitter podophyllol, but it passes through the unstable intermediate α-unsaturated podophyllol. In this paper, the process was tracked by 1H-NMR and common computer software, which proved that podophylloin dehydration did undergo the formation of α-unsaturated podophyllol. At the same time, it shows that computer simulation can be effectively used for the analysis of nuclear magnetic resonance spectrum.
keywords:
podophyllol α-unsaturated bitter podophyllol β-unsaturated bitter podophyl 1H-NMR analysis Volume 12 Issue podophyllotoxin α apopicropodophyllin β -apopicropodophyllin 1H-NMR analysis
Year:
2002
Last Update：2023-08-16 22:23:51
ACID(RG) - Preparation method of phosphoric acid and sulfonic acid ester of epodophyllipoplitin glycoside
from Baidu library
patent type:
patent for invention
application (patent) number:
CN92113431.2
date of application:
19891005
public/announcement number:
CN1071929A
date of publication/announcement:
19930512
Applicant (patentee):
Bristol-Mills Company
Inventor:
Onuma ,< a href = "https://xueshu.baidu.com/s?wd=author: (Yamazaki Tetsuji) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Yamazaki Tetsuji = "https://xueshu.baidu.com/s?wd=author: (Kamei Hideo) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Kamei Hideo ,< a href = "https://xueshu.baidu.com/s?wd=author: (Naito Takayuki) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Naito Takayuki ,< a href · solnier) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person "target ="_blank "> Mark Solnier
national and provincial code:
US
Summary:
The present invention relates to a preparation method for 4 & prime;-demethylation of podophylloidin glycosides with phosphate ester substituents or sulfonic ester substituents in the sugar part of the molecule. These compounds have anti-tumor effects.
Last Update：2023-08-16 22:23:51
ACID(RG) - Reference Information
| introduction | podophyllum resin is an antiviral agent, and its main components are podophyllum toxin, α-podophyllum fat toxin, β-podophyllum fat toxin and 4-podophyllum fat toxin, 4 kinds of lignans. It can inhibit the mitosis and synthesis of wart virus DNA, kill the virus, and has corrosive and keratinolytic effects. |
| application | podophyllum resin can be used to treat various viral warts, such as condyloma acuminatum, common warts, flat warts, plantar warts, skin cancer and limited keratosis skin diseases. |
| adverse reactions | after applying podophyllum resin, there may be mild burning sensation, edema and erosion in some cases, and excessive amount may cause systemic poisoning. |
Last Update：2024-04-09 21:21:28
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