ACM
Methyl acetoacetate
CAS: 105-45-3
Molecular Formula: C5H8O3
ACM - Names and Identifiers
| Name | Methyl acetoacetate |
| Synonyms | MAA ACM HYL ACETOACETATE Methyl acetoacetate Methyl acetoacetaten ACETYL METHYL ACETATE methyl 3-oxobutanoate ACETOACETIC ESTER (METHYL) ACETOACETIC ACID METHYL ESTER Acetoacetic acid methyl ester 3-OXOBUTYRIC ACID METHYL ESTER 3-OXBUTANOIC ACID METHYL ESTER 3-OXOBUTANOIC ACID METHYL ESTER |
| CAS | 105-45-3 |
| EINECS | 203-299-8 |
| InChI | InChI=1/C5H8O3/c1-4(6)3-5(7)8-2/h3H2,1-2H3 |
| InChIKey | WRQNANDWMGAFTP-UHFFFAOYSA-N |
ACM - Physico-chemical Properties
| Molecular Formula | C5H8O3 |
| Molar Mass | 116.12 |
| Density | 1.076 g/mL at 25 °C (lit.) |
| Melting Point | -80 °C (lit.) |
| Boling Point | 169-170 °C/70 mmHg (lit.) |
| Flash Point | 158°F |
| Water Solubility | 460 g/L (20 ºC) |
| Solubility | Soluble in water. |
| Vapor Presure | 1 hPa (20 °C) |
| Vapor Density | 4 (vs air) |
| Appearance | Transparent liquid |
| Color | APHA: ≤20 |
| Merck | 14,6009 |
| BRN | 506727 |
| pKa | 10.67±0.46(Predicted) |
| PH | 3.8 (863g/l, H2O, 20℃) |
| Storage Condition | 2-8°C |
| Sensitive | Easily absorbing moisture |
| Explosive Limit | 1.3-14.2%(V) |
| Refractive Index | n20/D 1.419(lit.) |
| MDL | MFCD00008784 |
| Physical and Chemical Properties | Characteristics of colorless transparent liquid, with aromatic flavor. melting point -80 ℃ boiling point 171.7 ℃ relative density 1.0762 refractive index 1.4184 flash point 70 ℃ solubility miscible with ethanol and ether, slightly soluble in water. |
| Use | For the pharmaceutical industry |
ACM - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 1 |
| RTECS | AK5775000 |
| TSCA | Yes |
| HS Code | 29183000 |
| Toxicity | LD50 orally in rats: 3.0 g/kg (Smyth, Carpenter) |
ACM - Upstream Downstream Industry
| Raw Materials | Methyl alcohol diketene |
| Downstream Products | Methyl 3-oxopentanoate 2,4-Dihydroxy-6-methylpyrimidine Pirimiphos-methyl Diazinon Nifedipine Nitrendipine 2-Propylvaleric acid sodium salt |
ACM - Nature
Open Data Verified Data
colorless transparent liquid with aromatic flavor. The relative density was 1. 0762. Melting Point -80 °c. Boiling point 171.7 °c. Refractive index 4184. The flash point was 70 °c. Miscible with ethanol and ether, slightly soluble in water. Slightly decomposed at boiling temperature. Dark red when mixed with fecl3.
Last Update：2025-06-10 22:55:16
ACM - Preparation Method
Open Data Verified Data
esterification of diketene with methanol using concentrated sulfuric acid as catalyst, followed by crude fractionation and distillation to obtain the finished product. Diketene is obtained by the cleavage of acetic acid. See ethyl acetoacetate.
Last Update：2022-01-01 10:33:31
ACM - Introduction
It has an aromatic flavor. It is miscible with ethanol and ether and soluble in 2 parts of water. It is dark red when mixed with ferric chloride. (Microdecomposition), slightly decomposed at boiling temperature. The median lethal dose (rat, oral) was 3.0 g/kg. Stimulant
Last Update：2022-10-16 17:11:42
ACM - Application
Open Data Verified Data
organic synthesis raw materials, cellulose resin solvent, used in medicine, Pesticide Synthesis.
Last Update：2025-08-19 16:24:40
ACM - Safety
Open Data Verified Data
- This product is less toxic, rat oral LD50 3.Og/ kg. The RAT test was exposed to concentrated vapor for 8 hours and no death was observed. There is a moderate degree of irritation and anesthesia. The equipment should be closed and the ventilation of the operating place should be strengthened. The operator shall wear protective equipment.
- This product is packaged in an aluminum barrel. Note that the lid is well sealed. Store in a cool and ventilated place. Fire Protection. According to the provisions of flammable and toxic chemicals storage and transportation.
Last Update：2022-01-01 10:33:31
ACM - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | methyl acetoacetate is an intermediate of fungicides hymmezol, dimethylsulfurol, ethylsulfurol, insecticides diazinon, pyrifos, pyrimidine oxyphosphorus, herbicide imidazoleetinic acid, rodenticide, rodenticide, rodenticide, rodenticide, rodenticide, etc. It is used as a solvent for cellulose ether and a mixed solvent for cellulose resin, and is also used in organic synthesis such as pesticides, medicines, dyes, and polymer stabilizers. Used in pharmaceutical industry organic synthesis. Solvent. |
| Production method | It is prepared by the reaction of diketene and methanol. Diketene and methanol are esterified with concentrated sulfuric acid as a catalyst, and then the finished product is obtained by crude fractionation and rectification. Diketene is obtained by cleavage of acetic acid. See "Ethyl acetoacetate". The preparation method of methyl acetoacetate is similar to the preparation method of ethyl acetoacetate. The crude product is obtained by the reaction of diketene and methanol under the catalysis of sulfuric acid, and the finished product is obtained by rectification. |
| auto-ignition temperature | 536 °F |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:05
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Raw Materials for ACM
Downstream Products for ACM