AFC
AFC
CAS: 135304-07-3
Molecular Formula: C20H33NO3S
AFC - Names and Identifiers
AFC - Physico-chemical Properties
| Molecular Formula | C20H33NO3S |
| Molar Mass | 367.55 |
| Density | 1.038±0.06 g/cm3(Predicted) |
| Boling Point | 566.1±50.0 °C(Predicted) |
| Solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml) |
| Appearance | Pale yellow oil. |
| Color | Yellow |
| pKa | 3.31±0.10(Predicted) |
| Storage Condition | -15°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| In vitro study | Arazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell. Arazine (10–100 μM;8 hours) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell. |
| In vivo study | Arazine (AFC) (2,000μg/20μl; applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED 50 ) of 55±12μg/20μl. Animal Model: TPA-induced ear acute inflammation in mouse Dosage: 2000μg/20μl Administration: 2000μg/20μl; Applied on ear Result: Inhibited ear edema, as measured by ear weight. |
AFC - Risk and Safety
| Hazard Class | IRRITANT |
AFC - Introduction
An AFC(N-acetyl-S-farnesyl-L-cysteine) is an organic compound with the following properties:
1. Physical properties: AFC is a white crystalline solid, soluble in water and organic solvents.
2. Chemical properties: the compound is a derivative of L-cysteine and farnesyl acetyl, and its acetyl moiety makes it have better solubility. It can act as a nucleophile or ligand in a chemical reaction.
3. Use: AFC is commonly used in the field of biochemical research and drug development. It plays an important role in protein ubiquitination, alcoholization and sulfylation. In addition, it can also be used in the synthesis of certain drugs or cosmetics.
4. Preparation method: AFC is usually obtained by chemical synthesis method. The general synthetic route is to react L-cysteine with farnesyl acetic anhydride, followed by the addition of an acetylating reagent for acetylation.
5. Safety Information: For the safety of AFC, there is no detailed toxicology study report. During use, appropriate laboratory safety measures should be taken to avoid contact with eyes, skin and inhalation of gases. If accidental contact occurs, rinse immediately with plenty of water and consult a professional doctor. During storage and handling, contact with oxidants and combustibles should be avoided and kept properly.
1. Physical properties: AFC is a white crystalline solid, soluble in water and organic solvents.
2. Chemical properties: the compound is a derivative of L-cysteine and farnesyl acetyl, and its acetyl moiety makes it have better solubility. It can act as a nucleophile or ligand in a chemical reaction.
3. Use: AFC is commonly used in the field of biochemical research and drug development. It plays an important role in protein ubiquitination, alcoholization and sulfylation. In addition, it can also be used in the synthesis of certain drugs or cosmetics.
4. Preparation method: AFC is usually obtained by chemical synthesis method. The general synthetic route is to react L-cysteine with farnesyl acetic anhydride, followed by the addition of an acetylating reagent for acetylation.
5. Safety Information: For the safety of AFC, there is no detailed toxicology study report. During use, appropriate laboratory safety measures should be taken to avoid contact with eyes, skin and inhalation of gases. If accidental contact occurs, rinse immediately with plenty of water and consult a professional doctor. During storage and handling, contact with oxidants and combustibles should be avoided and kept properly.
Last Update：2024-04-09 01:59:57
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CAS: 135304-07-3
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