AM-2394
AM-2394
CAS: 1442684-77-6
Molecular Formula: C22H25N5O4
AM-2394 - Names and Identifiers
AM-2394 - Physico-chemical Properties
| Molecular Formula | C22H25N5O4 |
| Molar Mass | 423.46 |
| Density | 1.266±0.06 g/cm3(Predicted) |
| Boling Point | 588.8±50.0 °C(Predicted) |
| Solubility | DMSO: ≥ 30 mg/mL |
| pKa | 12.66±0.70(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| In vivo study | AM-2394, a structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in ob/ob mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. AM-2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animal models. |
AM-2394 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.361 ml | 11.807 ml | 23.615 ml |
| 5 mM | 0.472 ml | 2.361 ml | 4.723 ml |
| 10 mM | 0.236 ml | 1.181 ml | 2.361 ml |
| 5 mM | 0.047 ml | 0.236 ml | 0.472 ml |
Last Update：2024-01-02 23:10:35
AM-2394 - Reference Information
| use | AM 2394 is a unique glucokinase activator (GKA). AM-2394 activates GK through an EC50 of 60 nM. |
| biological activity | AM-2394 is a new type of glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with EC50 of 60 nM. |
| target | EC50: 60 nM (glucokinase) |
| in vivo research | AM-2394, A structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in ob/ob mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animation models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. am -2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animation models. |
Last Update：2024-04-09 01:59:59
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