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AP20187

AP20187

CAS: 195514-80-8

Molecular Formula: C82H107N5O20

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AP20187 - Names and Identifiers

Name AP20187
Synonyms AP20187
AP-20187
AP 20187
AP20187 (AP-20187
(1S,1'S)-(((2,2'-((2-((dimethylamino)methyl)propane-1,3-diyl)bis(azanediyl))bis(acetyl))bis(oxy))bis(3,
(1R,1'R)-(((((2-((dimethylamino)methyl)propane-1,3-diyl)bis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) (2S,2'S)-bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate)
(S,2S,2'S)-(1R,1'R)-(((((2-((dimethylamino)methyl)propane-1,3-diyl)bis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate)
(1R)-3-(3,4-dimethoxyphenyl)-1-[3-[2-[[2-[[[2-[3-[(1R)-3-(3,4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetyl]amino]methyl]-3-(dimethylamino)propyl]amino]-2-oxoethoxy]phenyl]propyl] (2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate
CAS 195514-80-8

AP20187 - Physico-chemical Properties

Molecular FormulaC82H107N5O20
Molar Mass1482.75
Solubility DMSO: ≥ 57 mg/mL
Storage Condition-20℃
In vitro study When LNCaP cells are treated with AP20187 (B/B Homodimerizer) (100 nM), ro-iCaspase-9 levels are significantly reduced, and the smaller processed active caspase-9 becomes apparent.
In vivo study Real-time PCR analysis shows that AP20187 (B/B Homodimerizer) (0.5 mg/kg, 2 mg/kg, or 5 mg/kg) treatment significantly increases the levels of CHOP mRNA in the CNS of PLP/Fv2E-PERK mice at PID12. AP20187 treatment significantly alleviates EAE-induced myelin damage in these mice. AP20187 (B/B Homodimerizer) treatment significantly reduces the number of degenerating axons and increases the density of axons in the demyelinating lesions in the lumbar spinal cord of PLP/Fv2E-PERK mice.

AP20187 - Preparation solution concentration reference

 1mg5mg10mg
1 mM0.674 ml3.372 ml6.744 ml
5 mM0.135 ml0.674 ml1.349 ml
10 mM0.067 ml0.337 ml0.674 ml
5 mM0.013 ml0.067 ml0.135 ml
Last Update：2024-01-02 23:10:35

AP20187 - Reference Information

biological activity AP20187 (B/B Homodimerizer) is a cell-permeable molecule that dimerges FK506 binding protein (FKBP), initiates biological signal transduction cascade and gene expression, or destroys protein-protein interactions.
target FKBP homodimerizer
in vitro study when LNCaP cells are treated with AP20187 (B/B Homodimerizer) (100 nM), ro-iCaspase-9 levels are significantly reduced, and the smaller processed active caspase-9 becomes apparent.
in vivo study Real-time PCR analysis shows that AP20187 (B/B Homodimerizer) (0.5 mg/kg, 2 mg/kg, or 5 mg/kg) treatment significantly increases the levels of CHOP mRNA in the CNS of PLP/Fv2E-PERK mices at PID12. AP20187 treatment significantly alleviates EAE-induced myelin damage in these mices. AP20187 (B/B Homodimerizer) treatment significantly reduces the number of degenerating axons and increases the density of axons in the demyelinating lesions in the lumbar spinal cord of PLP/Fv2E-PERK mices.
Last Update：2024-04-09 21:11:58
AP20187
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Shanghai Macklin Biochemical Co., Ltd
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CAS: 195514-80-8
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: AP20187 Visit Supplier Webpage Request for quotation
CAS: 195514-80-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: AP20187 Visit Supplier Webpage Request for quotation
CAS: 195514-80-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Amole Biotechnology Co., Ltd.
Spot supply
Product Name: AP20187 Request for quotation
CAS: 195514-80-8
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
Wechat: 18916960931
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: AP20187 Visit Supplier Webpage Request for quotation
CAS: 195514-80-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
MedChemExpress (MCE)
Spot supply
Product Name: B/B Homodimerizer Visit Supplier Webpage Request for quotation
CAS: 195514-80-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: AP20187 Visit Supplier Webpage Request for quotation
CAS: 195514-80-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
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AP20187
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