AQ
1,2-DIPHENYLCYCLOPROPEN-3-ONE
CAS: 886-38-4
Molecular Formula: C15H10O
AQ - Names and Identifiers
AQ - Physico-chemical Properties
| Molecular Formula | C15H10O |
| Molar Mass | 206.24 |
| Density | 1.232 |
| Melting Point | 118-122 °C(lit.) |
| Boling Point | 305.09°C (rough estimate) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.6324 |
| MDL | MFCD00001311 |
AQ - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R38 - Irritating to the skin R43 - May cause sensitization by skin contact |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. |
AQ - Efficacy and safety analysis of diphenylcypropenone in the treatment of alopecia areata
From Wanfang
Author:
Summary:
background: alopecia areata (alopecia; AA) is a chronic inflammatory autoimmune skin disease involving hair follicles in the growing period, with a population incidence rate of about 1%-2%. It is characterized by scarless hair loss of the scalp and shedding of body hair in other parts. Alopecia areata can occur at any age, with no significant differences in race or sex. After months to years of onset, hair loss may automatically alleviate, or may persist, some patients to conventional treatment is not effective. There are many treatments for alopecia areata, such as hormones, minoxidil tincture, contact sensitizers, phototherapy, cyclosporine, etc. However, some retrospective analyses indicate that there is no real cure for alopecia areata. Because there are too many variables in alopecia areata research (such as course of disease, degree of alopecia, age of onset), and the disease has a certain self-healing, and the lack of a unified efficacy evaluation standard, the implementation of randomized controlled trials has become a huge challenge... Background: Alopecia areata (alopecia areata;AA) is a chronic inflammatory autoimmune skin disease involving hair follicles during the growth period, and the population incidence. It is characterized by scarless hair loss of the scalp and shedding of body hair in other parts. Alopecia areata can occur at any age, with no significant differences in race or sex. After months to years of onset, hair loss may automatically alleviate, or may persist, some patients to conventional treatment is not effective. There are many treatments for alopecia areata, such as hormones, minoxidil tincture, contact sensitizers, phototherapy, cyclosporine, etc. However, some retrospective analyses indicate that there is no real cure for alopecia areata. Because there are too many variables in alopecia areata research (such as course of disease, degree of alopecia, age of onset), and the disease has a certain self-healing, and the lack of uniform efficacy evaluation criteria, the implementation of randomized controlled trials has become a huge challenge. Previous studies have shown that local immunotherapy is currently the most clinically supported method for the treatment of extensive or refractory alopecia areata. Local immunotherapy was first proposed in the 2070s, which refers to the treatment of contact dermatitis induced by local use of sensitizers. In 1977, the sensitizer dinitrochlorobenzene (dinitrochlorobenzene; DNCB) was first used to treat alopecia areata. Since then, different types of sensitizers for the treatment of alopecia areata have been discovered. Later, the sensitizer dibutyl squaric acid dibutylester; SADBE) was found to have unstable solution properties and mutagenicity of DNCB, so diphenylcyclopropenone (diphenylcyclopropenone; DPCP) has become the first choice for sensitizers due to its stability and safety. Recent studies have shown that DPCP is widely used in local treatment, and refractory alopecia areata is safe and effective. Objective: To observe the efficacy and side effects of diphenylcypropenone in the treatment of extensive, refractory alopecia areata, and to evaluate the prognostic factors. Methods: Diphenylcypropenone was used in the treatment of 52 patients with extensive, refractory alopecia areata. According to the clinical data obtained,: the study included 52 patients (26 men and 26 women) with extensive and refractory alopecia areata, with an average age of 30.81±14.28 years and an average course of 3.69±4.71 years. All patients were treated for not less than 3 months, of which 21 (40.4%) obtained complete response (complete response:>90% hair rebirth),6 (11.5%) obtained partial response (partial response:>50-90% hair rebirth),5 (9.6%) obtained minimal response (minimum response: 10-50% hair rebirth),20 (38.5%) did not respond (no response:<10% hair newborn). the average time to complete response was 8.67±4.53 months. Side effects include blisters and severe local irritation (57.7%), pigmentation (36.5%), cervical lymph node enlargement (19.2%), urticaria (5.8%), facial swelling (1.9%), erythema multiforme (1.9%) and extreme pruritus (1.9%). In patients with complete response, the total recurrence rate is 66.7%. Chronic course (≥ 10 years) is significantly related to poor prognosis (≤ 50% hair regeneration). in the maintenance and non-maintenance groups, the recurrence time was 6 months 8.1 and 7 months 4.1, respectively (P = 0.049). conclusion: diphenylcypropenone is widely treated, and the efficacy of refractory alopecia areata is definite and tolerable. Alopecia areata duration ≥ 10 years is associated with poor prognosis. Maintenance therapy may delay recurrence. Pack up
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Degree level:
master's degree
Degree year:
2015
Last Update：2024-01-02 23:10:35
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