ARV-825
ARV-825
CAS: 1818885-28-7
Molecular Formula: C46H47ClN8O9S
ARV-825 - Names and Identifiers
ARV-825 - Physico-chemical Properties
| Molecular Formula | C46H47ClN8O9S |
| Molar Mass | 923.43 |
| Density | 1.47±0.1 g/cm3(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 10.74±0.40(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| In vitro study | In Burkitt's lymphoma cells, ARV-825 treatment resulted in more significant changes in c-MYC levels and downstream cell proliferation and apoptosis induction compared to other BRD4 inhibitors. Co-incubated with ARV-825 for 72 hours, ARV-825 had IC50 values in the 2-50 nM range against the cell lines tested and primary AML cells. In AML cells, ARV-825 reduces PIM1 levels and CXCR4 phosphorylation levels, and overexpression of PIM1 or CXCR4 reverses this effect. |
| In vivo study | In the mouse model transplanted with human leukemia cells, the leukemia burden of the mice in the ARV-825 experimental group was significantly lower than that of the control group, and the survival time was longer than that of the control group. |
ARV-825 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.083 ml | 5.415 ml | 10.829 ml |
| 5 mM | 0.217 ml | 1.083 ml | 2.166 ml |
| 10 mM | 0.108 ml | 0.541 ml | 1.083 ml |
| 5 mM | 0.022 ml | 0.108 ml | 0.217 ml |
Last Update：2024-01-02 23:10:35
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Product Name: ARV-825 Visit Supplier Webpage Request for quotationCAS: 1818885-28-7
Tel: +16314854226
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Product List: View Catalog
Product Name: ARV-825 Visit Supplier Webpage Request for quotation
CAS: 1818885-28-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1818885-28-7
Tel: 18301782025
Email: 3008007409@qq.com
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View History
ARV-825
5560-62-3
4441-12-7
408-27-5
1932-50-9
5818-06-4
617-62-9
17264-53-8
109-64-8
1-Propylpropargyl alcohol
5560-62-3
4441-12-7
408-27-5
1932-50-9
5818-06-4
617-62-9
17264-53-8
109-64-8
1-Propylpropargyl alcohol