Afatinib
Tovok,BIBW 2992
CAS: 439081-18-2;850140-72-6
Molecular Formula: C24H25ClFN5O3
Afatinib - Names and Identifiers
| Name | Tovok,BIBW 2992 |
| Synonyms | Tovok Afatinb AFATINIB BIBW2992 Afatinib BIBW 2992 BIBW2992 BIBW-2992 BIBW-2292 Afatinib(W.S) Tovok,BIBW 2992 Afatinib(cis-trans isomerismtautomers) (S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dim (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl}-4-(dimethylamino)but-2-enamide (E)-N-(7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide 2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydro-3-furanyl)oxy)-6-quinazolinyl)-4-(dimethylamino)- |
| CAS | 439081-18-2 850140-72-6 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+ |
Afatinib - Physico-chemical Properties
| Molecular Formula | C24H25ClFN5O3 |
| Molar Mass | 485.94 |
| Density | 1.380 |
| Boling Point | 676.9±55.0 °C(Predicted) |
| Flash Point | 363.186°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 12.06±0.43(Predicted) |
| Storage Condition | -20 ° C, dark |
| Refractive Index | 1.668 |
| In vitro study | BIBW2992 irreversibly inhibits EGFR/HER2, and its IC50 is 0.5, 0.4, 10, and 14 nM when it acts on wild-type EGFR, L858R mutant EGFR, L858R/T790M double mutant EGFR, and HER2 in vitro, respectively. In the in vitro experiment, BIBW2992 showed strong vitality whether acting on wild-type EGFR/HER2 or mutant EGFR/HER2, which was similar to that of gefitinib acting on L858R mutant EGFR, however, it is 100 times more active than gefitinib in the L858R-T790M double mutant EGFR. In Vitro, BIBW2992 potently inhibited EGFR/HER phosphorylation in all cell types tested. Such as wild-type EGFR expressed by human flat epithelial carcinoma A431 cell line, wild-type HER2 transfected by murine NIH-3T3 cells, and endogenous HER2 expressed by breast cancer BT-474 cell lines and gastric cancer NCI-N87 cell lines. |
| In vivo study | In vivo study, according to the body weight of the experimental subjects, 20 mg BIBW2992 per kilogram was taken orally for 25 days, and the tumor produced obvious recession phenomenon, which was observed by immunohistochemical staining of tumor sections, the phosphorylation of EGFR and AKT was inhibited. Thus, like lapatinib and neratinib, BIBW2992 is a secondary tyrosine kinase inhibitor that irreversibly inhibits human EGFR2(HER2) and EGFR kinases. BIBW2992 is not only as effective as primary tyrosine kinases such as erlotinib and gefitinib in inhibiting EGFR mutants, but also acts on EGFR resistant to erlotinib and gefinib. |
Afatinib - Risk and Safety
| HS Code | 29349990 |
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Mobile: +86-18821248368
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WhatsApp: +86-18821248368
Featured ProductsMultiple SpecificationsSpot supply
Product Name: BIBW 2992 Visit Supplier Webpage Request for quotationCAS: 850140-72-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Multiple SpecificationsSpot supply
Product Name: Afatinib Request for quotationCAS: 850140-72-6
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Multiple SpecificationsSpot supply
Product Name: Afatinib E-Isomer Visit Supplier Webpage Request for quotationCAS: 850140-72-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Afatinib Visit Supplier Webpage Request for quotationCAS: 850140-72-6
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Afatinib Visit Supplier Webpage Request for quotationCAS: 439081-18-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Multiple SpecificationsSpot supply
Product Name: Afatinib Visit Supplier Webpage Request for quotationCAS: 850140-72-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
Afatinib
31301-45-8
96034-57-0
100-88-9
119-65-3
104-14-3
40283-46-3
Phenylhydrazine
AKOS JY2083685
894085-97-3
31301-45-8
96034-57-0
100-88-9
119-65-3
104-14-3
40283-46-3
Phenylhydrazine
AKOS JY2083685
894085-97-3