Albiflorin
Albiflorin
CAS: 39011-90-0
Molecular Formula: C23H28O11
Albiflorin - Names and Identifiers
| Name | Albiflorin |
| Synonyms | ALBIFLORIN Albiflorin Alibiflorin Albiflorin std Albiflorin, froM Paeonia lactiflora 4-hydroxy-6-methyl-, (1R, 3R, 4R, 6S)- [(benzoyloxy)methyl]-1-(β-D-glucopyranosyloxy)- 9-((Benzoyloxy)methyl)-1-(beta-D-glucopyranosyloxy)-4-hydroxy-6-methyl-7-oxatricyclononan-8-one [1-(beta-D-glucopyranosyloxy)-4-hydroxy-6-methyl-8-oxo-7-oxatricyclo[4.3.0.0~3,9~]non-9-yl]methyl benzoate Albiflorin 9-((Benzoyloxy)methyl)-1-(beta-D-glucopyranosyloxy)-4-hydroxy-6-methyl-7-oxatricyclononan-8-one [(1R,4R,6S)-1-(beta-D-glucopyranosyloxy)-4-hydroxy-6-methyl-8-oxo-7-oxatricyclo[4.3.0.0~3,9~]non-9-yl]methyl benzoate (1R,3R,4R,6S,9S)-9-[(Benzoyloxy)Methyl]-1-(beta-D-glucopyranosyloxy)-4-hydroxy-6-Methyl-7-oxatricyclo[4.3.0.03,9]nonan-8-one |
| CAS | 39011-90-0 |
| InChI | InChI=1/C23H28O11/c1-21-8-13(25)12-7-23(21,33-19-17(28)16(27)15(26)14(9-24)32-19)22(12,20(30)34-21)10-31-18(29)11-5-3-2-4-6-11/h2-6,12-17,19,24-28H,7-10H2,1H3/t12?,13-,14-,15-,16+,17-,19+,21+,22?,23+/m1/s1 |
Albiflorin - Physico-chemical Properties
| Molecular Formula | C23H28O11 |
| Molar Mass | 480.46 |
| Density | 1.58±0.1 g/cm3(Predicted) |
| Boling Point | 722.1±60.0 °C(Predicted) |
| Specific Rotation(α) | -19.9 (c, 0.95 in EtOH) |
| Flash Point | 248.934°C |
| Solubility | Soluble in water. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White amorphous powder |
| pKa | 12.84±0.70(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Refractive Index | 1.662 |
| MDL | MFCD00238531 |
| Physical and Chemical Properties | Roots of Paeonia lactiflora Paeonia albiflora Pall from Ranunculaceae |
Albiflorin - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29389090 |
Albiflorin - Reference
| Reference Show more | 1. Ye Xiao, Liu Xiaoqian, Gao Huimin, et al. Determination of total triterpenoid saponins in Chinese traditional medicine with Akebia saponins as an example [J]. Chinese Journal of Traditional Chinese Medicine 2019(14). 2. Liu Liang, Jing Yu, Zhang Qiang et al. Effects of processing methods on chemical constituents of Paeonia lactiflora pall. [J]. Shi Zhen Guomai National Medicine 2020 v.31;No.294(02):93-95. 3. Hu Xinyu, Wang Xue, Lu Wenqian, et al. Protective Mechanism of albiflorin on PC12 cell injury induced by MPP ^ [J]. Chinese Journal of Pharmacy, 2016. 4. Yan Hongli, Ma Xutong, Deng Xiuping, etc. Establishment of HPLC fingerprint of Angelica sinensis and Paeonia lactiflora Pall [J]. Chinese traditional medicines, 2020, 042(005):1376-1379. 5. Xu Yuan, Liu Pei, Yan Hui, et al. Analysis of monoterpene glycosides and polyhydroxy compounds during the initial processing of Paeonia lactiflora pall. [J]. Chinese Herbal Medicine, 2014, 25 (5):775-780. 6. Li Dongyun, Cao Xiulian, Ren Yanqing, etc. Effect of solid particles in decoction of Paeonia lactiflora pall on intestinal absorption of total glucosides of paeony [J]. Hebei Journal of Traditional Chinese Medicine, 2018(2):26-29. 7. Yu Xian Hua Gao Haiyan Jin Chuan Shan, etc. Fingerprint of standard decoction of Paeonia lactiflora pall from different habitats and determination of four monoterpene glycosides [J]. Chinese Journal of Modern Applied Pharmacy 2020(11):1290-1295. 8. Mo Yujia, Wang Yan, Qi Qi, et al. Establishment of HPLC fingerprint of the classic decoction and study on the value transfer of chuanxiong [J]. Chinese Journal of Traditional Chinese Medicine, 2020, v.45(03):122-128. 9. Zhang Jiajia, Ma Chi, Zhu Zhiling, Zhang Songbai, Zhang Xun. Simultaneous determination of five components in Radix Paeoniae Alba by HPLC [J]. Fujian traditional Chinese medicine 2019 50(01):66-67 70. 10. Zhao qiulong, bianxiaokun, Qian Dawei, Zhang Ting, Zhu Zhenhua, Guo Sheng, Yan Hui, Wang Tuanfeng, Chen Zhipeng, Duan Jinyu. Comparative study on the difference of Paeonia lactiflora pall. From different habitats based on UPLC fingerprint and chemometrics [J]. Chinese Journal of Traditional Chinese Medicine, 2019,44(15):3316-3322. 11. Wang Hua, He Danyu, Zhu Liangyu, etc. Simultaneous determination of nine active components in Radix Paeoniae rubra by HPLC [J]. Chinese herbal medicine, 2018, 049(003):708-711. 12. Liang de Qin, Zhao Yuan Yuan, Luo Yun, etc. HPLC fingerprints and multi-component content comparison of Paeonia lactiflora pall with different processing methods [J]. Journal of Anhui University of Traditional Chinese Medicine, 2018. 13. Fu shimong, Shen Hongwei, Wang Qianbo, etc. Evaluation of quality of Radix Paeoniae rubra from different areas by fingerprint combined with gray correlation analysis [J]. Chinese Herbal Medicine, Volume 50, Issue 23, page 5865-5871, ISTIC PKU CSCD CA, 2019. 14. Fu shimong, Shen Hongwei, Wang Qianbo, etc. Optimization of processing technology for Radix Paeoniae rubra slices [J]. Chinese patent medicine, 2019(8). 15. Zhao Yuanyuan, Liang Deqin, Jin Chuanshan, Wei Qinghong, Zhang Wei, Xu Fengqing, Wang Lin. Determination of seven components in standard decoction of different processed products of Radix Paeoniae Alba based on HPLC fingerprint [J]. Natural product research and development, 2018,30(03):404-411 500. 16. Cheng Jiang-Xue, Tang Zhi-shu, Guo Dong-yan, et al. Effect of different compatibility ratio on dissolution of 10 components in Radix Paeoniae rubra-radix angelicae Sinensis [J]. Journal of Pharmaceutical Analysis, 2019, v.39(09):73-80. 17. Xu Chao, Lin Jie, Jin Chuanshan, Liu Junling. Comparison of chemical constituents of Paeonia lactiflora pall with different growth years by HPLC fingerprint combined with Chemometrics [J]. Chinese herbal medicine, 2021,52(08):2408-2413. 18. Peng Ping, Xiong shaoxhe, Zhang Bei, Yi Jianping, Du Jing, Yang Xuan, fan Guoqiang, Gu Gul, Wang Zhibin. Study on quality evaluation of Qinlian preparation based on quality characterization of the whole party characteristic spectrum [J]. Chinese herbal medicine, 2021,52(05):1312-1322. 19. Zhang, Jing, et al. "Application of" spider-web "mode in discovery and identification of Q-markers from Xuefu Zhuyu capsule. Phytopedicine77 (2020): 153273.https://doi.org/10.1016/j.phymed.2020.153273 20. Li-Mei Feng, Yan-Yan Chen, Ding-Qiao Xu, Rui-Jia Fu, Shi-Jun Yue, Qi Zhao, Yu-Xi Huang, Xue Bai, Mei Wang, Li-Ming Xing, Yu-Ping Tang, Jin-Ao Duan,An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropa 21. Li-Mei Feng, Yan-Yan Chen, Ding-Qiao Xu Rui-Jia Fu, Shi-Jun Yue, Qi Zhao, Yu-Xi Huang, Xue Bai, Mei Wang, Li-Ming Xing, Yu-Ping Tang, Jin-Ao Duan,An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropa 22. Du, Kang, et al. "Chemical profiling and marker characterization of Huangqin decoction prepared with three types of peony root by liquid chromatography with electrospray ionization mass spectrometry." Journal of separation science 43.13 (2020): 2558-2570.h 23. [IF=1.902] Xiujun Wu et al."Simultaneous determination of ginsenoside Rb1, ginsenoside Rg1, paeoniflorin albiflorin and oxypaeoniflorin in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study of wen-Yang-Huo-Xue soft 24. [IF=6.576] Luo Zhiqiang et al."Mechanism of Paeoniae Radix Alba in the Treatment of Non-alcoholic Fatty Liver Disease Based on Sequential Metabolites Identification Approach, Network Pharmacology, and Binding Affinity Measurement."Front Nutr. 2021 Sep;0:674 25. [IF=5.645] Zhang-Zhen Bai et al."Comparative investigation on metabolites and biological activities of Paeonia ostii stamens from different geographical regions of China."Ind Crop Prod. 2021 Nov;172:114038 26. [IF=4.36] Qiyang Shou et al."Total glucosides of peony improve ovalbumin-induced allergic asthma by inhibiting mast cell degranulation."J Ethnopharmacol. 2019 Nov;244:112136 27. [IF=4.36] Li-Mei Feng et al."An integrated strategy for discovering effective components of Shaoyao Gancao decoction for treating neuropathic pain by the combination of partial least-squares regression and multi-index comprehensive method."J Ethnopharmacol. 2020 Oc 28. [IF=4.142] Hu Guizhou et al."An integrated strategy for the identification and screening of anti-allergy components from natural products based on calcium fluctuations and cell extraction coupled with HPLC-Q-TOF-MS."Anal Bioanal Chem. 2021 Oct;413(25):6253-6266 29. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4 30. [IF=3.645] Kang Du et al."Chemical profiling and marker characterization of Huangqin decoction prepared with three types of peony root by liquid chromatography with electrospray ionization mass spectrometry."J Sep Sci. 2020 Jul;43(13):2558-2570 |
Albiflorin - Introduction
Pharmacological effects: analgesic, sedative, anticonvulsant effects, effects on the immune system, effects on smooth muscle, anti-inflammatory effects, anti-pathogenic microorganisms, liver protection effects.
Last Update：2022-10-16 17:25:03
Albiflorin - Introduction
Albiflorin is an active ingredient extracted from Paeoniae Radix Alba, which belongs to a glycoside compound chemically. Its chemical structure is A molecule of glucose linked to A glycoside group, which is attached to the ring of the white peony lactone structure.
Albiflorin has a variety of biological activities, such as anti-inflammatory, antioxidant, antibacterial and anti-tumor. It is widely used in the field of traditional Chinese medicine to treat inflammation, promote blood circulation and relieve liver diseases. Albiflorin can inhibit inflammation and reduce the damage caused by inflammation, and also has a certain effect on improving the body's antioxidant capacity.
The preparation method of Albiflorin is mainly extracted from Radix Paeoniae Alba. In General, extraction and purification can be carried out by water, ethanol or other solvents. The extract obtained by extraction also needs to go through processes such as evaporation and freeze-drying, and finally the crystal or powder of Albiflorin is obtained.
When using Albiflorin, pay attention to the following safety information. First of all, Albiflorin is a natural product and is relatively safe in most cases. However, for pregnant women, children and lactating women, as well as individuals with allergic reactions, it is recommended to use under the guidance of a professional. Secondly, try to avoid exposure to high temperature, humidity and light and other factors, so as not to reduce the stability of Albiflorin. Finally, when storing Albiflorin, keep it in a dry, clean, dark place, and away from children.
In General, Albiflorin, as an active ingredient, has a wide range of application prospects in the field of Chinese medicine, and has a certain degree of safety. However, in the process of use, it is still necessary to pay attention to the rational use of drugs, follow the guidance of professionals, and properly preserve.
Albiflorin has a variety of biological activities, such as anti-inflammatory, antioxidant, antibacterial and anti-tumor. It is widely used in the field of traditional Chinese medicine to treat inflammation, promote blood circulation and relieve liver diseases. Albiflorin can inhibit inflammation and reduce the damage caused by inflammation, and also has a certain effect on improving the body's antioxidant capacity.
The preparation method of Albiflorin is mainly extracted from Radix Paeoniae Alba. In General, extraction and purification can be carried out by water, ethanol or other solvents. The extract obtained by extraction also needs to go through processes such as evaporation and freeze-drying, and finally the crystal or powder of Albiflorin is obtained.
When using Albiflorin, pay attention to the following safety information. First of all, Albiflorin is a natural product and is relatively safe in most cases. However, for pregnant women, children and lactating women, as well as individuals with allergic reactions, it is recommended to use under the guidance of a professional. Secondly, try to avoid exposure to high temperature, humidity and light and other factors, so as not to reduce the stability of Albiflorin. Finally, when storing Albiflorin, keep it in a dry, clean, dark place, and away from children.
In General, Albiflorin, as an active ingredient, has a wide range of application prospects in the field of Chinese medicine, and has a certain degree of safety. However, in the process of use, it is still necessary to pay attention to the rational use of drugs, follow the guidance of professionals, and properly preserve.
Last Update：2024-04-09 21:01:54
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