Angoroside
Angoroside C
CAS: 115909-22-3
Molecular Formula: C36H48O19
Angoroside - Names and Identifiers
| Name | Angoroside C |
| Synonyms | Angoroside Angoroside C ANGOROSIDE C Angelo glycosides C β-D-Glucopyranoside, 2-(3-hydroxy-4-methoxyphenyl)ethyl O-α-L-arabinopyranosyl-(1→6)-O-[6-deoxy-α-L-mannopyranosyl-(1→3)]-, 4-[(2E)-3-(4-hydroxy-3-methoxyphenyl)-2-propenoate] [(2R,3R,4R,5R,6R)-5-Hydroxy-6-[2-(3-hydroxy-4-methoxyphenyl)ethoxy]-4-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2-[[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxymethyl]oxan-3-yl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate |
| CAS | 115909-22-3 |
| InChI | InChI=1/C36H48O19/c1-16-26(41)28(43)30(45)36(52-16)55-33-31(46)35(49-11-10-18-5-8-22(47-2)20(38)12-18)53-24(15-51-34-29(44)27(42)21(39)14-50-34)32(33)54-25(40)9-6-17-4-7-19(37)23(13-17)48-3/h4-9,12-13,16,21,24,26-39,41-46H,10-11,14-15H2,1-3H3/b9-6+/t16-,21-,24+,26+,27-,28+,29+,30+,31+,32+,33+,34-,35+,36-/m0/s1 |
Angoroside - Physico-chemical Properties
| Molecular Formula | C36H48O19 |
| Molar Mass | 784.75 |
| Density | 1.54±0.1 g/cm3(Predicted) |
| Melting Point | 317-322°C |
| Boling Point | 985.7±65.0 °C(Predicted) |
| Specific Rotation(α) | (c, 0.38 in MeOH)-80.4 |
| Flash Point | 301.7°C |
| Solubility | DMSO : 250 mg/mL (318.57 mM; Need ultrasonic) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Yellow powder |
| pKa | 9.73±0.31(Predicted) |
| Storage Condition | -20℃ |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.651 |
| MDL | MFCD09752673 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Scrophulariae Scrophularia ningpoensis Hemsl. The rhizome. |
| In vivo study | Angoroside C has beneficial effects against ventricular remodeling. The mechanism is likely to be related to decreasing the level of Ang Ⅱ, attenuating the mRNA expressions of ET-1 and TGF-β1. |
Angoroside - Reference
| Reference Show more | 1. He Shiru, Li Li, Xu Guangming, et al. Rapid Determination of Active Components of Scrophulariae by Solid Phase Extraction and High Performance Liquid Chromatography [J]. Asia Pacific Traditional Medicine, 2020, 016(001):54-57. 2. Liu Fang, Huang Xiaojie, Lin Meiyu, et al. Research on Grade Quality of Scrophulariae [J]. New Drugs and Clinical Pharmacology of Traditional Chinese Medicine, Volume 31, 202020, Issue 8, pp. 978-983, ISTIC PKU CSCD CA, 2020. 3. Li Li Zhou Xiaojiang Yuan Zhiying et al. Determination of five index components in Scrophulariae by Dispersive Solid Phase Extraction HPLC [J]. Strait Pharmaceutical 2019 031(011):30-33. 4. Zhu Xiaofu, Deng Caifu, Tan Qiusheng, Yang Dan, Lu Shenge, Ren Fengming. Quality Evaluation of Different "Sweating" Days of Scrophulariae Produced in Chongqing [J]. Traditional Chinese medicine and clinic, 2020,11(05):8-10. 5. [IF = 2.63] Sun Ke-han et al."Comparative Pharmacokinetics of Seven Major Compounds in Normal and Atherosclerosis of Mice after Oral Administration of Simiao Yong'an Decoction." Evidence-based Complementary and Alternative Medicine. 2022;2022:4604601 |
Angoroside - Reference Information
| biological activity | Angoroside C is a phenylpropanoside extracted from Radix Scrophulariae, which is beneficial to ventricular remodeling. |
| in vivo studies | Angoroside C has beneficial effects against ventricular remodeling. the mechanism is likely to be related to decreasing the level of Ang ii, attenuating the mRNA expressions of ET-1 and TGF-β1. |
| chemical properties | white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Scrophulariae Scrophularia ningpoensis Hemsl. The rhizome. |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: the repair of DNA bases damaged by free radicals, the effect of inflammatory mediators on white blood cells, anti-platelet aggregation and liver protection. The free radical scavenger isolated and purified from the traditional Chinese medicine Scrophulariae has significant anti-inflammatory activity. |
Last Update：2024-04-09 21:54:55
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