Atipamezole
Atipamezole
CAS: 104054-27-5
Molecular Formula: C14H16N2
Atipamezole - Names and Identifiers
| Name | Atipamezole |
| Synonyms | MPV-1248 Atipamezole 104054-27-5 atipamezole 4-(2-Ethyl-2-indanyl)imidazole 5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole 5-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole 1H-Imidazole, 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)- 1H-imidazole, 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)- |
| CAS | 104054-27-5 |
| EINECS | 1806241-263-5 |
| InChI | InChI=1/C14H16N2/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14/h3-6,9-10H,2,7-8H2,1H3,(H,15,16) |
Atipamezole - Physico-chemical Properties
| Molecular Formula | C14H16N2 |
| Molar Mass | 212.29 |
| Density | 1.115±0.06 g/cm3(Predicted) |
| Melting Point | 126-129oC |
| Boling Point | 367.1±11.0 °C(Predicted) |
| Flash Point | 178°C |
| Solubility | DMSO: ≥30mg/mL |
| Vapor Presure | 2.95E-05mmHg at 25°C |
| Appearance | off-white to yellowish crystal powder |
| Color | white to brown |
| pKa | 14.05±0.10(Predicted) |
| Storage Condition | room temp |
| Refractive Index | 1.594 |
| MDL | MFCD00864502 |
| In vitro study | The affinity of atipamezole for α 2 -adrenoceptors and its α 2 /α 1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α 2 -adrenoceptors. It has negligible affinity for 5-HT 1 , 5-HT2 and I2 bindings sites. |
| In vivo study | Atipamezole is well tolerated in rodents. In anesthetized, normotensive rats, the cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals, but not necessarily on short-term working memory. |
Atipamezole - Risk and Safety
| WGK Germany | 3 |
Atipamezole - Reference Information
| Biological activity | Atipamezole (MPV-1248, MPV1248, Antisedan) is a synthetic α2 adrenergic receptor antagonist. As a potential drug against Parkinson's disease, it has been studied in humans. |
| Target | Value |
Last Update：2024-04-09 21:11:58
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