Azilsartan
Azilsartan
CAS: 147403-03-0
Molecular Formula: C25H20N4O5
Azilsartan - Names and Identifiers
Azilsartan - Physico-chemical Properties
| Molecular Formula | C25H20N4O5 |
| Molar Mass | 456.45 |
| Density | 1.42 |
| Melting Point | 188 °C(dec.) |
| Solubility | DMSO: soluble15mg/mL (clear solution) |
| Appearance | powder |
| Color | white to beige |
| pKa | 2.05±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| MDL | MFCD00916395 |
| In vitro study | Azilsartan inhibits the increase in plasma glucose levels in the oral glucose tolerance test (OGTT),Azilsartan inhibits the increase in plasma glucose levels without significantly altering insulin concentrations or increasing insulin sensitivity. In skeletal muscle, the 0.001% dose of Azilsartan reduced the expression of TNF-α. In adipose tissue, Azilsartan decreased TNF-α expression, but increased adiponectin, PPARγ,C/ebα, and AP2. Azilsartan enhances adipogenesis in cultured 3T3-L1 preadipocytes, acting on the genes encoding peroxisome proliferator-activated receptor-α (PPARα),PPAR δ, leptin, lipase, and the expression of adiponectin, more effective than valsartan. Azilsartan also effectively inhibited vascular cell proliferation in the absence of exogenous supplemented angiotensin II. |
| In vivo study | In Koletsky rats, Azilsartan treatment reduces blood pressure, basal plasma insulin concentration and homeostasis Pattern Assessment of insulin resistance index, and inhibits excessive increases in blood glucose and insulin concentration in the oral glucose tolerance test. Azilsartan down-regulates the expression of 11 β-hydroxysteroid dehydrogenase type 1. |
Azilsartan - Risk and Safety
| WGK Germany | 3 |
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Featured ProductsSpot supply
Product Name: Azilsartan Visit Supplier Webpage Request for quotationCAS: 147403-03-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Azilsartan Request for quotationCAS: 147403-03-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Azilsartan Visit Supplier Webpage Request for quotationCAS: 147403-03-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: TAK-536 Visit Supplier Webpage Request for quotationCAS: 147403-03-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Azilsartan Visit Supplier Webpage Request for quotationCAS: 147403-03-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Multiple SpecificationsSpot supply
Product Name: Azilsartan Visit Supplier Webpage Request for quotationCAS: 147403-03-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
Azilsartan
2'-DEOXYGUANOSINE
4-dodecyloxy-2-hydroxybenzophenone
Hsdb 7577
FEMA 3433
cyclohexane diammoniate
APY0201
2'-DEOXYGUANOSINE
4-dodecyloxy-2-hydroxybenzophenone
Hsdb 7577
FEMA 3433
cyclohexane diammoniate
APY0201