BAY-876
BAY-876
CAS: 1799753-84-6
Molecular Formula: C24H16F4N6O2
BAY-876 - Names and Identifiers
BAY-876 - Physico-chemical Properties
| Molecular Formula | C24H16F4N6O2 |
| Molar Mass | 496.4164 |
| Melting Point | >250oC (dec.) |
| Solubility | DMSO: ≥ 100 mg/mL |
| Appearance | Morphological powder |
| Color | white to beige |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Bioactive BAY-876 is an effective and selective GLUT1 inhibitor (IC50=0.002 μM), and its selectivity for GLUT1 is 100 times higher than that for GLUT2, GLUT3 and GLUT4. |
BAY-876 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.014 ml | 10.072 ml | 20.144 ml |
| 5 mM | 0.403 ml | 2.014 ml | 4.029 ml |
| 10 mM | 0.201 ml | 1.007 ml | 2.014 ml |
| 5 mM | 0.04 ml | 0.201 ml | 0.403 ml |
Last Update：2024-01-02 23:10:35
BAY-876 - Uses and synthesis methods
Target
Target Value
GLUT1
(Cell-free assay) 0.002 μM
in vitro studies
BAY-876 is an inhibitor with high selectivity to GLUT1, and its selectivity is 4700, 800 and 135 times to GLUT2, GLUT3 and GLUT4 respectively.
In vivo studies
BAY-876 has a low clearance rate in rats and dogs. Its volume of distribution is moderate, with a half-life of 2.5 hours in rats and 22 hours in dogs. The oral bioavailability (F%) in rats and dogs was 85% and 79%, respectively. BAY-876 has good in vivo pharmacokinetics (high oral bioavailability and long half-life), making it a chemical probe marker with great potential for targeting GLUT1 inhibitors in cancer treatment.
Last Update：2024-04-10 22:29:15
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Tel: 400-968-2212
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