BI-847325
BI-847325
CAS: 1207293-36-4
Molecular Formula: C29H28N4O2
BI-847325 - Names and Identifiers
BI-847325 - Physico-chemical Properties
| Molecular Formula | C29H28N4O2 |
| Molar Mass | 464.56 |
| Solubility | DMSO: ≥36 mg/mL |
| Storage Condition | -20℃ |
| In vitro study | BI-847325 showed growth inhibition in BRAF mutant and vemurafenib resistant melanoma cells with an IC50 in the range of 0.3 nM-2 μm and prevented colony formation in six BRAF mutant melanoma cell lines. BI-847325 also induces apoptosis by reducing Mcl-1 expression. |
| In vivo study | In mice loaded with 1205Lu and 1205LuR xenografts, BI-847325 (75 mg/kg, p.o.) caused significant tumor regression without significant change in body weight. |
BI-847325 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.153 ml | 10.763 ml | 21.526 ml |
| 5 mM | 0.431 ml | 2.153 ml | 4.305 ml |
| 10 mM | 0.215 ml | 1.076 ml | 2.153 ml |
| 5 mM | 0.043 ml | 0.215 ml | 0.431 ml |
Last Update：2024-01-02 23:10:35
BI-847325 - Reference Information
| biological activity | BI-847325 is an oral selective dual MEK/Aurora kinase inhibitor with biological activity. the IC50 for Xenopus Aurora B, human Aurora A and Aurora C, and human MEK1 and MEK2 are 3 nM,25 nM,15 nM respectively, 25 nM, and 4 nM. Phase 1. |
| target | TargetValue Aurora B (Xenopus laevis) 3 nM MEK2 4 nM Aurora C (Human) 15 nM Aurora A (Human) 25 nM MEK1 25 nM |
| Target | Value |
| Aurora B (Xenopus laevis) | 3 nM |
| MEK2 | 4 nM |
| Aurora C (Human) | 15 nM |
| Aurora A (Human) | 25 nM |
| MEK1 | 25 nM |
| in vitro study | BI-847325 showed growth inhibition on BRAF mutant and vemurafenib resistant melanoma cells, with IC50 ranging from 0.3 nM-2 μM and preventing colony formation in 6 BRAF mutant melanoma cell lines. BI-847325 also induce apoptosis by reducing Mcl-1 expression. |
| in vivo study | in mice loaded with 1205Lu and 1205LuR xenografts, BI-847325 (75 mg/kg, p.o.) caused significant tumor degeneration without significant weight change. |
Last Update：2024-04-09 21:54:55
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Product Name: 3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide Request for quotationCAS: 1207293-36-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: BI-847325 Visit Supplier Webpage Request for quotationCAS: 1207293-36-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: BI-847325 Visit Supplier Webpage Request for quotationCAS: 1207293-36-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: BI-847325 Visit Supplier Webpage Request for quotationCAS: 1207293-36-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: BI-847325 Visit Supplier Webpage Request for quotationCAS: 1207293-36-4
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Product Name: BI-847325 Visit Supplier Webpage Request for quotation
CAS: 1207293-36-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1207293-36-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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