BML-284
BML-284
CAS: 853220-52-7
Molecular Formula: C19H18N4O3
BML-284 - Names and Identifiers
BML-284 - Physico-chemical Properties
| Molecular Formula | C19H18N4O3 |
| Molar Mass | 350.37 |
| Density | 1.353±0.06 g/cm3(Predicted) |
| Boling Point | 623.4±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 30 mg/mL |
| Appearance | Yellowish sticky solid |
| Color | white to beige |
| pKa | 6.62±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | BML-284 (10 µM; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen.BML-284 (10 µM; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group. Western Blot Analysis Cell Line: Human gastric cancer cell lines MNK45 and AGS [1] Concentration: 10 µM Incubation Time: 24 hours Result: Induced β-catenin expression and reserved E-cadherin and N-cadherin expression in MNK45 and AGS cells. |
| In vivo study | BML-284 (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos. |
BML-284 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| WGK Germany | 3 |
BML-284 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.854 ml | 14.271 ml | 28.541 ml |
| 5 mM | 0.571 ml | 2.854 ml | 5.708 ml |
| 10 mM | 0.285 ml | 1.427 ml | 2.854 ml |
| 5 mM | 0.057 ml | 0.285 ml | 0.571 ml |
Last Update：2024-01-02 23:10:35
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