BQ-123
BQ-123 SODIUM SALT
CAS: 136553-81-6
Molecular Formula: C31H42N6O7
BQ-123 - Names and Identifiers
BQ-123 - Physico-chemical Properties
| Molecular Formula | C31H42N6O7 |
| Molar Mass | 610.7 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Boling Point | 1053.6±65.0 °C(Predicted) |
| Appearance | lyophilized powder |
| pKa | 4.04±0.10(Predicted) |
| Storage Condition | -20°C |
| In vitro study | In porcine aortic vascular smooth muscle cells, BQ-123 selectively inhibited ETA-mediated contraction. In rat vascular smooth muscle cells, BQ-123 inhibited inositol phosphate breakdown and DNA synthesis induced by endothelin-1. |
| In vivo study | In rats, BQ-123 (1 mg/kg, I. v.) ameliorated myocardial ischemia-reperfusion injury. In rats with pentylenetetrazol (PTZ)-induced tonic-clonic seizures, BQ-123 (3 mg/kg, I. v.) effectively prevented the formation and development of epilepsy. In pregnant C57BL/6 mice, BQ-123 (6.7 mg/kg, I. p.) prevented LPS-induced preterm birth in mice by inducing IL-10 in the uterus and placenta. |
BQ-123 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
BQ-123 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.637 ml | 8.187 ml | 16.375 ml |
| 5 mM | 0.327 ml | 1.637 ml | 3.275 ml |
| 10 mM | 0.164 ml | 0.819 ml | 1.637 ml |
| 5 mM | 0.033 ml | 0.164 ml | 0.327 ml |
Last Update：2024-01-02 23:10:35
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