BQU57
BQU57
CAS: 1637739-82-2
Molecular Formula: C16H13F3N4O
BQU57 - Names and Identifiers
BQU57 - Physico-chemical Properties
| Molecular Formula | C16H13F3N4O |
| Molar Mass | 334.3 |
| Density | 1.43±0.1 g/cm3(Predicted) |
| Boling Point | 493.4±45.0 °C(Predicted) |
| Solubility | DMSO: ≥ 36 mg/mL |
| pKa | 2.92±0.40(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | In the H2122 and H358 cell lines, BQU57 inhibited RalA and RalB activation, resulting in cell growth inhibition. |
| In vivo study | In mice bearing human lung H2122 tumors, BQU57 (50 mg/kg, I. p.) significantly inhibited the activation of RalA and RalB and caused dose-dependent tumor growth inhibition. |
BQU57 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.991 ml | 14.957 ml | 29.914 ml |
| 5 mM | 0.598 ml | 2.991 ml | 5.983 ml |
| 10 mM | 0.299 ml | 1.496 ml | 2.991 ml |
| 5 mM | 0.06 ml | 0.299 ml | 0.598 ml |
Last Update：2024-01-02 23:10:35
BQU57 - Reference Information
| biological activity | BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to GTPases Ras and RhoA. |
| target | TargetValue GTPase Ral () |
| Target | Value |
| in vitro study | in H2122 and H358 cell lines, BQU57 inhibits the activation of RalA and RalB, thus causing cell growth inhibition. |
| in vivo study | in mice loaded with human lung H2122 tumors, BQU57 (50 mg/kg, I. p.) significantly inhibited the activation of RalA and RalB and caused dose-dependent tumor growth inhibition. |
Last Update：2024-04-09 21:04:16
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