BUTENAFINE
Butenafine
CAS: 101828-21-1
Molecular Formula: C23H27N
BUTENAFINE - Names and Identifiers
| Name | Butenafine |
| Synonyms | BUTENAFINE Butenafine 4-tert-Butylbenzylmethyl 1-naphtylmethylamine (4-tert-butylbenzyl)-methyl-(1-naphthylmethyl)amine N-methyl-N-(4-methylbenzyl)-N-(1-naphthylmethyl)amine n-(p-tert-butylbenzyl)-n-methyl-1-naphthalenemethylamine N-(4-tert-Butylbenzyl)-N-methyl-1-naphthalenemethanamine 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine n-methyl-n-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine N-Methyl-N-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine |
| CAS | 101828-21-1 |
| InChI | InChI=1/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3 |
BUTENAFINE - Physico-chemical Properties
| Molecular Formula | C23H27N |
| Molar Mass | 317.47 |
| Density | 1.032±0.06 g/cm3(Predicted) |
| Melting Point | 200-202 °C |
| Boling Point | 426.1±14.0 °C(Predicted) |
| pKa | 7.87±0.50(Predicted) |
| Use | Used as an antifungal agent |
| In vitro study | Butenafine demonstrates comparable activity against the dermatophytes with a MIC range of 0.03-0.25 μg/ml. It displays limited activity against the yeast Candida albicans and no activity against Malassezia furfur .Butenafine (25; 50 or 100 μM) eliminates the promastigote forms of L. amazonensis and L. braziliensis in a dose-dependent manner, and shows EC 50 values of 34.10±3.76 μM and 81.25±10.24 μM, respectively, in peritoneal macrophages from BALB/c mice. Butenafine induces mild cytotoxicity in peritoneal macrophages from BALB/c mice with a CC 50 of 97.88 μM. |
| In vivo study | Butenafine (subcutaneous administration; 1-100 mg/kg) to mice has no effect on the central and autonomic nervous systems. Topical administration of 0.3-3.0% butenafine solutions to guinea pigs also has no effect on the somatic nervous system.In primary therapeutic studies on guinea pigs, Butenafine (1% topical application; 4-10 days; day 3 and 4 post-infection) exhibits a complete cure after 10 days in vivo-effect on dermatophytosis, T. mentagrophytes .Butenafine (0.125, 0.25, 0.5 and 1.0% topical application; q.d. or b.i.d. for 10 days; day 4 post-infection) exhibits a 100% cure after 0.5% or 1% application and has no difference in efficacy between 1% q.d. and b.i.d. in vivo-effect on dermatophytosis, T. mentagrophytes. |
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