| Molecular Formula | C33H44FN5O3 |
| Molar Mass | 577.73 |
| Solubility | DMSO: ≥ 300 mg/mL |
| Storage Condition | -20℃ |
| In vitro study | TSR-011 has high affinity for wild type recombinant ALK kinase activity, IC50 is 0.7 nM; Inhibition of tropomyosin receptor kinase (TRK)A, B, C(IC50 less than 3 nM). |
| In vivo study | In a mouse model, TSR-011 was able to exert potent, durable inhibition of ALK-dependent tumor growth. It was well tolerated. |
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.731 ml | 8.655 ml | 17.309 ml |
| 5 mM | 0.346 ml | 1.731 ml | 3.462 ml |
| 10 mM | 0.173 ml | 0.865 ml | 1.731 ml |
| 5 mM | 0.035 ml | 0.173 ml | 0.346 ml |