Boc-Glycine
BOC-Glycine
CAS: 4530-20-5
Molecular Formula: C7H13NO4
Boc-Glycine - Names and Identifiers
| Name | BOC-Glycine |
| Synonyms | Boc-Gly-OH Boc-glycin BOC-Glycine BOC-L-GLY-OH N-Boc-glycine glycine(sterile) N-tert-Boc-glycine-OH NtertButoxycarbonylglycine N-tert-Butoxycarbonylglycine N-(tert-Butoxycarbonyl)glycine N-ALPHA-T-BUTYLOXYCARBONYL-GLYCINE [(tert-butoxycarbonyl)amino]acetate n-[(1,1-dimethylethoxy)carbonyl]-glycin Boc-Gly-OH~N-(tert-Butoxycarbonyl)glycine BOC-GLYCINE(N-TERT-BUTOXYCARBONYLGLYCINE) |
| CAS | 4530-20-5 |
| EINECS | 224-864-5 |
| InChI | InChI=1/C7H13NO4/c1-7(2,3)12-6(11)8-4-5(9)10/h4H2,1-3H3,(H,8,11)(H,9,10)/p-1 |
Boc-Glycine - Physico-chemical Properties
| Molecular Formula | C7H13NO4 |
| Molar Mass | 175.18 |
| Density | 1.2843 (rough estimate) |
| Melting Point | 86-89°C(lit.) |
| Boling Point | 306.47°C (rough estimate) |
| Flash Point | 144.9°C |
| Water Solubility | soluble |
| Solubility | Soluble in Chloroform. |
| Vapor Presure | 9.08E-05mmHg at 25°C |
| Appearance | White crystal |
| Color | White to off-white |
| BRN | 1101514 |
| pKa | 4.00±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.4353 (estimate) |
| MDL | MFCD00002690 |
| Physical and Chemical Properties | White Crystal or crystalline powder; Soluble in ethyl acetate and alkali solution, insoluble in water and petroleum ether; mp is 88-89 °c. |
| Use | For the synthesis of proteins and peptides, widely used in the synthesis of pharmaceutical biochemistry, food, cosmetics and other products |
Boc-Glycine - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S39 - Wear eye / face protection. S36 - Wear suitable protective clothing. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29241990 |
Boc-Glycine - Introduction
Soluble in water.
Last Update：2022-10-16 17:25:17
Boc-Glycine - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| application | Boc-glycine is mainly used in polypeptide synthesis, mainly used in a variety of drugs and biotechnology applications. Glycine has a wide range of uses and functions. Protecting glycine with Boc as a protective group is an important intermediate raw material for many kinds of medicine and biotechnology. |
| preparation | 1. add 18.1gL-glycine and 100ml water to the reaction bottle and stir. Add 16g of 0.01mol/L lye of sodium hydroxide to alkaline. Add 8g of (Boc)2O for 2 hours, 8g of (Boc)2O for 2 hours, and finally 9g of (Boc)2O for 4 hours. 2. Use n-hexane 12ml/time to extract impurities three times. After 3mol/L hydrochloric acid adjusts PH = 3, dioxane is used to 0.6L/time to extract the product three times. Combine ester layers and wash with brine to neutral. Add 15 grams of anhydrous sodium sulfate and dry for 10 hours. 3. Filter, concentrate and dry the filtrate under reduced pressure, add 60ml of n-hexane, stir and crystallize. Centrifuge out the product and dry it. The product 25.0g is obtained. The yield is 93.87%. |
| Use | Used for polypeptide synthesis and as an amino acid protective monomer. It is used in the synthesis of proteins and peptides, and is widely used in the synthesis of pharmaceutical biochemistry, food, cosmetics and other products. |
| production method | using tert-butoxycarbonyl azide and glycine as raw materials, react in dioxane solution to obtain crude product, and then extract and recrystallize with ethyl acetate to obtain pure product. |
Last Update：2024-04-09 21:11:58
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