CALCEIN

CALCEIN - Names and Identifiers

Name	Calcein
Synonyms	Calcein CALCEIN CALCEINE Oftasceine CALCEIN, INDICATOR FLUORESCEIN COMPLEXON FLUORESCEIN COMPLEXONE FLUORESCEIN-METHYLENE-IMINODIACETIC ACID BIS[N,N-BIS(CARBOXYMETHYL)AMINOMETHYL]FLUORESCEIN FLUORESCEIN-2,7-BIS-METHYLIMINODIACETIC SODIUM SALT 2,2',2'',2'''-[(3',6'-dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-2',7'-diyl)bis(methanediylnitrilo)]tetraacetic acid
CAS	1461-15-0
EINECS	215-957-1
InChI	InChI=1/C30H26N2O13/c33-21-7-23-19(5-15(21)9-31(11-25(35)36)12-26(37)38)30(18-4-2-1-3-17(18)29(43)45-30)20-6-16(22(34)8-24(20)44-23)10-32(13-27(39)40)14-28(41)42/h1-8,33-34H,9-14H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)

CALCEIN - Physico-chemical Properties

Molecular Formula	C30H26N2O13
Molar Mass	622.53
Density	1.4388 (rough estimate)
Melting Point	200 °C
Boling Point	662.7°C (rough estimate)
Flash Point	530°C
Water Solubility	insoluble
Solubility	H2O: soluble
Vapor Presure	0mmHg at 25°C
Appearance	Yellow powder
Color	Yellow-orange to orange-brown
Maximum wavelength(λmax)	['494nm']
pKa	6.67(at 25℃)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Stability	Stable. Incompatible with strong oxidizing agents.
Sensitive	Easily absorbing moisture
Refractive Index	1.5800 (estimate)
MDL	MFCD00005049
Use	Determination of calcium, steel, strontium, copper and manganese by complexing indicator
In vitro study	Calcein accumulates intracellularly in coelomocytes incubated in coelomic fluid or ISO-EDTA. Coelomocytes incubated in CF show an increase in the calcein fluorescence intensity compared to the control.

CALCEIN - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
FLUKA BRAND F CODES	10
HS Code	32041900

CALCEIN - Reference

Reference

1. Tian Tao, Fu Qiang, Zhu Jiankui et al. Observation on the Benefit of Erzhi Pill in Treating Zebrafish Osteoporosis Model and the Mechanism of Osteoclast Autophagy [J]. Journal of Nanjing University of Traditional Chinese Medicine 2020 v.36(03):78-83.
2. Lin Ziwei, Yang Fei, Huang Tianyi, et al. Study on the Effect of Paeoniflorin on Osteoblast Apoptosis and Anti-osteoporosis [J]: 426-431.
3. Yan, Xiao-Xiao; Liu, Jing-Quan; Jiang, Shui-Dong; Yang, Bin; Yang, Chun-Sheng: 'Tapered metal microneedles fabricated by the human process of mechanical dicing and electrochemical corrosion for drug delivery', Micro & Nano Letters, 2012, 7, (12), p. 1
4. Yan, Xiao-Xiao, et al. "Fabrication and testing analysis of tapered silicon microneedles for drug delivery applications." Microelectronic engineering 111 (2013): 33-38.https:// doi.org/10.1016/j.mee. 2013.04.039
5. [IF=2.523] Xiao-Xiao Yan et al."Fabrication and testing analysis of tapered silicon microneedles for drug delivery applications."Microelectron Eng. 2013 Nov;111:33
6. [IF=8.694] Zheng Zhang et al."FOS/GOS attenuates high-fat diet induced bone loss via reversing microbiota dysbiosis, high intestinal permeability and systemic inflammation in mice."Metabolism. 2021 Jun;119:154767
7. [IF=7.514] Linlin Fan et al."Stable vesicle self-assembled from phospholipid and mannosylerythritol lipid and its application in encapsulating anthocyanins."Food Chem. 2021 May;344:128649
8. [IF=6.529] Wei-ni Qin et al."The toxicity mechanism of toxic compounds from Euphorbiae pekinensis Radix on zebrafish embryos."Biomed Pharmacother. 2021 Jun;138:111521
9. [IF=4.011] Yang F. et al."Ligustilide, a major bioactive component of Angelica sinensis , promotes bone formation via the GPR30/EGFR pathway."Sci Rep-Uk. 2019 May;9(1):1-10
10. [IF=3.935] Hui Jiang et al."Preparation of covalently bonded liposome capillary column and its application in evaluation of drug membrane permeability."J Pharmaceut Biomed. 2022 Feb;209:114513

CALCEIN - Reference Information

pH indicator color change ph range	Weak green 'uorescence (6.0) to strong green 'uorescence (7.2)
biological application	Calcium indicator; fluoride indicator; iron indicator; mercury indicator; detecting nucleic acids,proteins; treating osteoporosis; drug delivery systems
main applications	Chemical-mechanical polishing, stabilizing liposomes, cell motility say, detecting nucleic acids, virus, screening safety of gastric mcosa, MDR inhibitors, delivery, imaging atherosclerotic plaque
EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
biological activity	Calcein is a fluorescent dye and self-extinguishing probe, which can be used as an indicator of lipid vesicle leakage, and can also be used as a complexing indicator for EDTA calcium ion titration and fluorescence determination of calcium ions.
Use	Complexation indicator is used for the determination of calcium, steel, strontium, copper, manganese, etc. Used for fluorescence determination of calcium, or EDTA titration of calcium in the presence of magnesium.

Last Update：2024-04-09 21:22:08

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CALCEIN

CALCEIN

Calcein

CAS: 1461-15-0

Molecular Formula: C30H26N2O13

CALCEIN - Names and Identifiers

CALCEIN - Physico-chemical Properties

CALCEIN - Risk and Safety

CALCEIN - Reference

CALCEIN - Reference Information

Supplier List

CALCEIN Request for Quotation

Calcein

CAS: 1461-15-0

Molecular Formula: C30H26N2O13

CALCEIN - Names and Identifiers

CALCEIN - Physico-chemical Properties

CALCEIN - Risk and Safety

CALCEIN - Reference

CALCEIN - Reference Information

Supplier List

CALCEIN